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Birth weight is the most important predictor of abnormal retinal vascularisation in moderately preterm infants.

Artikel i vetenskaplig tidskrift
Författare Kerstin Allvin
Ann Hellström
Jovanna Dahlgren
Marita Andersson Grönlund
Publicerad i Acta paediatrica (Oslo, Norway : 1992)
Volym 103
Nummer/häfte 6
Sidor 594–600
ISSN 1651-2227
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 594–600
Språk en
Länkar dx.doi.org/10.1111/apa.12599
Ämnesord Birth size;Insulin-like growth factor-I;Pre-eclampsia;Retinal vascularisation;Small for gestational age
Ämneskategorier Pediatrik

Sammanfattning

Aim To find predictors of abnormal retinal vascularisation in moderately to late preterm newborn infants considered to have no risk of developing retinopathy of prematurity. Methods Seventy-eight infants (34 girls) were recruited from a longitudinal study of otherwise healthy premature children born at a gestational age of 32+0-36+6weeks. Retinal vessel morphology was evaluated at mean postnatal age 7days. Insulin-like growth factor-I (IGF-I) levels were analysed in umbilical cord blood. Results Of the 78 infants, 21 (27%) had abnormal retinal vessel morphology; they had significantly lower median (range) birth weight [1850g, (1190-3260), vs. 2320, (1330-3580), p<0.0001], shorter birth length [43.0cm, (38-49), vs. 46.0, (40-50), p<0.0001] and smaller head circumference [31.0cm, (27.7-34.0), vs. 32.0, (27.5-36.5), p=0.003]. They also had significantly lower gestational age [34+1weeks, (32+2-35+3), vs. 34+6, (32+2-36+6), p=0.004] and meanSD IGF-I levels (24.6 +/- 17.0g/L vs. 46.7 +/- 21.5, p<0.0001). A higher percentage of these infants were small for gestational age (57.1% vs. 15.8%, p=0.001), and maternal hypertension/preeclampsia rates were also higher (47.6% vs. 19.3%, p=0.03). Step-wise logistic regression showed that birth weight was the strongest predictor of abnormal retinal vascularisation (p<0.0001, odds ratio 0.040, 95% confidence interval 0.007-0.216). Conclusion In this population of moderately to late preterm newborns, birth weight appeared to affect the retinal vascular system.

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