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Biomarker Evidence of Axonal Injury in Neuroasymptomatic HIV-1 Patients

Artikel i vetenskaplig tidskrift
Författare Jan Jessen Krut
Tomas Mellberg
R.W. Price
Lars Hagberg
D. Fuchs
Lars Rosengren
Staffan Nilsson
Henrik Zetterberg
Magnus Gisslén
Publicerad i PLoS ONE
Volym 9
Nummer/häfte 2
Sidor Art. no. e88591
ISSN 1932-6203
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för matematiska vetenskaper, matematisk statistik
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor Art. no. e88591
Språk en
Länkar dx.doi.org/10.1371/journal.pone.008...
https://gup.ub.gu.se/file/198815
Ämnesord Albumins, blood counts, brain damage, Cerebrospinal fluid, HIV, HIV infections, Central nervous system, Neuropsychological testing
Ämneskategorier Neurokemi, Klinisk medicin

Sammanfattning

Prevalence of neurocognitive impairment in HIV-1 infected patients is reported to be high. Whether this is a result of active HIV-related neurodegeneration is unclear. We examined axonal injury in HIV-1 patients by measuring the light subunit of neurofilament protein (NFL) in CSF with a novel, sensitive method.With a cross-sectional design, CSF concentrations of neurofilament protein light (NFL) (marker of neuronal injury), neopterin (intrathecal immunoactivation) and CSF/Plasma albumin ratio (blood-brain barrier integrity) were analyzed on CSF from 252 HIV-infected patients, subdivided into untreated neuroasymptomatics (n = 200), HIV-associated dementia (HAD) (n = 14) and on combinations antiretroviral treatment (cART) (n = 85), and healthy controls (n = 204). 46 HIV-infected patients were included in both treated and untreated groups, but sampled at different timepoints. Furthermore, 78 neuroasymptomatic patients were analyzed before and after treatment initiation. While HAD patients had the highest NFL concentrations, elevated CSF NFL was also found in 33% of untreated neuroasymptomatic patients, mainly in those with blood CD4+ cell counts below 250 cells/μL. CSF NFL concentrations in the untreated neuroasymptomatics and treated groups were equivalent to controls 18.5 and 3.9 years older, respectively. Neopterin correlated with NFL levels in untreated groups while the albumin ratio correlated with NFL in both untreated and treated groups. Increased CSF NFL indicates ongoing axonal injury in many neuroasymptomatic patients. Treatment decreases NFL, but treated patients retain higher levels than controls, indicating either continued virus-related injury or an aging-like effect of HIV infection. NFL correlates with neopterin and albumin ratio, suggesting an association between axonal injury, neuroinflammation and blood-brain barrier permeability. NFL appears to be a sensitive biomarker of subclinical and clinical brain injury in HIV and warrants further assessment for broader clinical use.

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