Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12
| Författare |
Viktor Dahl Magnus Gisslén Lars Hagberg Julia Peterson Wei Shao Serena Spudich Richard W Price Sarah Palmer |
|---|---|
| Publicerad i | The Journal of infectious diseases |
| Volym | 209 |
| Nummer/häfte | 10 |
| Sidor | 1618-1622 |
| ISSN | 1537-6613 |
| Publiceringsår | 2014 |
| Publicerad vid |
Institutionen för biomedicin, avdelningen för infektionssjukdomar |
| Sidor | 1618-1622 |
| Språk | en |
| Länkar |
dx.doi.org/10.1093/infdis/jit805 |
| Ämneskategorier | Infektionsmedicin |
We sequenced HIV-1 in 70 CSF and 29 plasma samples and the corresponding pre-therapy samples from 17 subjects on suppressive therapy. More of the CSF sequences were hypermutants than plasma sequences. We generated on-therapy sequences from both CSF and plasma from two subjects; in one we found genetically distinct sequences in CSF and plasma indicating that they came from two different compartments, one potentially the CNS, during suppressive therapy. In addition, there was little evidence of viral evolution in the CSF during therapy, suggesting that continuous virus replication is not the major cause of viral persistence in the CNS.
GÖTEBORGS UNIVERSITET • Box 100 • 405 30 Göteborg • Telefon: 031 786 0000
Kontakt • Organisationsnummer: 202100-3153 • Om webbplatsen
Facebook
Twitter
Instagram
Snapchat
Youtube