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Blunted Metabolic Responses to Cold and Insulin Stimulation in Brown Adipose Tissue of Obese Humans

Artikel i vetenskaplig tidskrift
Författare J. Orava
P. Nuutila
T. Noponen
R. Parkkola
T. Viljanen
Sven Enerbäck
A. Rissanen
K. H. Pietilainen
K. A. Virtanen
Publicerad i Obesity
Volym 21
Nummer/häfte 11
Sidor 2279-2287
ISSN 1930-7381
Publiceringsår 2013
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik
Sidor 2279-2287
Språk en
Länkar dx.doi.org/10.1002/oby.20456
Ämnesord ENDOTHELIAL FUNCTION, WEIGHT-LOSS, GLUCOSE, SENSITIVITY, RESISTANCE, EXPOSURE, CLAMP, RATS, FRONZO RA, 1979, AMERICAN JOURNAL OF PHYSIOLOGY, V237, PE214, ATES OF AMERICA, V109, P10001
Ämneskategorier Endokrinologi, Endokrinologi och diabetes

Sammanfattning

Objective: Inactive brown adipose tissue (BAT) may predispose to weight gain. This study was designed to measure metabolism in the BAT of obese humans, and to compare it to that in lean subjects. The impact of weight loss on BAT and the association of detectable BAT with various metabolic characteristics were also assessed. Design and Methods: Using positron emission tomography (PET), cold-and insulin-stimulated glucose uptake and blood flow in the BAT of obese and lean humans were quantified. Further, cold-induced glucose uptake was measured in obese subjects before and after a 5-month conventional weight loss. Results: Mean responses in BAT glucose uptake rate to both cold and insulin stimulation were twice as large in lean as in obese subjects. Blood flow in BAT was also lower in obese subjects under cold conditions. The increase in cold-induced BAT glucose uptake rate after weight loss was not statistically significant. Subjects with cold-activated detectable BAT were leaner and had higher whole-body insulin sensitivity than BAT-negative subjects, irrespective of age and gender. Conclusions: The effects of cold and insulin on BAT activity are severely blunted in obesity, and the presence of detectable BAT may contribute to a metabolically healthy status.

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