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Importance of vasoactive intestinal polypeptide in the regulation of burn perfusion.

Artikel i vetenskaplig tidskrift
Författare Lucky Lindblom
Jean Cassuto
Liselotte Yregård
Peter Tarnow
Johanna Räntfors
Pia Löwhagen Hendén
Publicerad i Burns : journal of the International Society for Burn Injuries
Volym 26
Nummer/häfte 5
Sidor 435-42
ISSN 0305-4179
Publiceringsår 2000
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för plastikkirurgi
Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 435-42
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Analysis of Variance, Animals, Blood Pressure, drug effects, Burns, classification, physiopathology, Cardiovascular Physiological Phenomena, drug effects, Confidence Intervals, Heart Rate, drug effects, Immune Sera, pharmacology, Ischemia, physiopathology, Laser-Doppler Flowmetry, Male, Rats, Rats, Sprague-Dawley, Regional Blood Flow, drug effects, Skin, blood supply, injuries, Sodium Chloride, Sympathetic Nervous System, drug effects, Vasoactive Intestinal Peptide, antagonists & inhibitors, pharmacology, Vasodilator Agents, antagonists & inhibitors, pharmacology
Ämneskategorier Anestesi och intensivvård

Sammanfattning

Vasoactive intestinal polypeptide is one of the body's most potent vasodilators and has been shown to increase blood flow in a number of tissues. Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns. Systemic administration of VIP elicited a significant drop in mean arterial blood pressure versus saline (p<0.001) and VIP antiserum (p<0.001) both in burned and nonburned animals. VIP also decreased heart rate versus saline (p<0.05) and anti-VIP (p<0.001) in nonburned and burned animals. In contrast, VIP antiserum significantly increased blood pressure (p<0. 001) and heart rate (p<0.001) versus saline in all the groups. Skin perfusion in normal skin was significantly impaired by VIP infusions as compared to saline (p<0.01) while VIP-antiserum did not differ significantly from saline. Similarly, VIP significantly reduced blood flow versus saline-treatment in partial-thickness (p<0.01) and full-thickness burns (p<0.05) while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment. The present results show that VIP is directly involved in general cardiovascular control but plays a minor role in the maintenance of skin perfusion following a thermal injury as suggested by the lack of effect of VIP-antiserum. In contrast, exogenous administration of VIP significantly and dramatically impaired skin perfusion in normal and burned skin probably by increasing blood flow in organs of higher priority such as the brain and heart and concomitantly inducing a pronounced vasoconstriction in the skin, probably as a result of increased sympathetic effect on peripheral organs in order to maintain blood pressure.

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