Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän

Nutritional status modula… - Göteborgs universitet Till startsida
Till innehåll Läs mer om hur kakor används på gu.se

Nutritional status modulates plasma leptin, AMPK and TOR activation, and mitochondrial biogenesis: Implications for cell metabolism and growth in skeletal muscle of the fine flounder

Artikel i vetenskaplig tidskrift
Författare E. N. Fuentes
D. Safian
Ingibjörg Einarsdottir
J. A. Valdes
A. A. Elorza
A. Molina
Björn Thrandur Björnsson
Publicerad i General and Comparative Endocrinology
Volym 186
Sidor 172-180
ISSN 0016-6480
Publiceringsår 2013
Publicerad vid Institutionen för biologi och miljövetenskap
Sidor 172-180
Språk en
Länkar dx.doi.org/10.1016/j.ygcen.2013.02....
Ämnesord Cell metabolism, Growth, Skeletal muscle, Signaling pathways, Nutritional status, Fish, fatty-acid oxidation, trout oncorhynchus-mykiss, acetyl-coa carboxylase, protein-kinase, rainbow-trout, gene-expression, food-intake, signaling, pathways, carassius-auratus, mammalian target
Ämneskategorier Zoologi, Marin ekologi


Insight of how growth and metabolism in skeletal muscle are related is still lacking in early vertebrates. In this context, molecules involved in these processes, such as leptin, AMP-activated protein kinase (AMPK), target of rapamicyn (TOR), peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α, and oxidative phosphorylation complexes (OXPHOS), were assessed in the skeletal muscle of a fish species. Periods of fasting followed by a period of refeeding were implemented, using the fine flounder as a model (Paralichthys adspersus). This species exhibits remarkably slow growth and food intake, which is linked to an inherent growth hormone (GH) resistance and high circulating levels of leptin. Leptin increased during fasting concomitantly with AMPK activation, which was inversely correlated with TOR activation. On the other hand, AMPK was directly correlated with an increase in PGC-1α and OXPHOS complexes contents. Dramatic changes in the activation and content of these molecules were observed during short-term refeeding. Leptin, AMPK activation, and PGC-1α/OXPHOS complexes contents decreased radically; whereas, TOR activation increased significantly. During long-term refeeding these molecules returned to basal levels. These results suggest that there is a relation among these components; thus, during fasting periods ATP-consuming biosynthetic pathways are repressed and alternative sources of ATP/energy are promoted, a phenomenon that is reversed during anabolic periods. These results provide novel insight on the control of metabolism and growth in the skeletal muscle of a non-mammalian species, suggesting that both processes in fish muscle are closely related and coordinated by a subset of common molecules.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?