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Serotonin transporter occupancy with TCAs and SSRIs: a PET study in patients with major depressive disorder.

Artikel i vetenskaplig tidskrift
Författare Johan Lundberg
Mikael Tiger
Mikael Landén
Christer Halldin
Lars Farde
Publicerad i The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
Volym 15
Nummer/häfte 8
Sidor 1167-72
ISSN 1469-5111
Publiceringsår 2012
Publicerad vid
Sidor 1167-72
Språk en
Ämnesord Adult, Antidepressive Agents, Tricyclic, pharmacology, therapeutic use, Benzylamines, pharmacokinetics, Carbon Radioisotopes, pharmacokinetics, Depressive Disorder, Major, drug therapy, radionuclide imaging, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Positron-Emission Tomography, Protein Binding, drug effects, Serotonin Plasma Membrane Transport Proteins, metabolism, Serotonin Uptake Inhibitors, pharmacology, therapeutic use, Young Adult
Ämneskategorier Klinisk medicin, Psykiatri

Sammanfattning

The aim of the present clinical positron emission tomography study was to examine if the 5-HTT is a common target, both for tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). Serotonin transporter (5-HTT) occupancy was estimated during treatment with TCA, SSRI and mirtazapine in 20 patients in remission from depression. The patients were recruited from out-patient units and deemed as responders to antidepressive treatment. The radioligand [¹¹C]MADAM was used to determine the 5-HTT binding potential. The mean 5-HTT occupancy was 67% (range 28-86%). There was no significant difference in 5-HTT occupancy between TCA (n=5) and SSRI (n=14). 5-HTT affinity correlated with the recommended clinical dose. Mirtazapine did not occupy the serotonin transporter. The results support that TCAs and SSRIs have a shared mechanism of action by inhibition of 5-HTT.

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