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Examining and interpreting the female protective effect against autistic behavior

Artikel i vetenskaplig tidskrift
Författare E. B. Robinson
P. Lichtenstein
Henrik Anckarsäter
F. Happe
A. Ronald
Publicerad i Proceedings of the National Academy of Science of the United States of America
Volym 110
Nummer/häfte 13
Sidor 5258-5262
ISSN 0027-8424
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 5258-5262
Språk en
Länkar dx.doi.org/10.1073/pnas.1211070110
Ämnesord epidemiology, genetics, family studies
Ämneskategorier Medicinska grundvetenskaper

Sammanfattning

Male preponderance in autistic behavioral impairment has been explained in terms of a hypothetical protective effect of female sex, yet little research has tested this hypothesis empirically. If females are protected, they should require greater etiologic load to manifest the same degree of impairment as males. The objective of this analysis was to examine whether greater familial etiologic load was associated with quantitative autistic impairments in females compared with males. Subjects included 3,842 dizygotic twin pairs from the Twins Early Development Study (TEDS) and 6,040 dizygotic twin pairs fromthe Child and AdolescentTwin Study of Sweden (CATSS). In both samples, we compared sibling autistic traits between female and male probands, who were identified as children scoring in the top 90th and 95th percentiles of the population autistic trait distributions. In both TEDS and CATSS, siblings of female probands above the 90th percentile had significantly more autistic impairments than the siblings of male probands above the 90th percentile. The siblings of female probands above the 90th percentile also had greater categorical recurrence risk in both TEDS and CATSS. Results were similar in probands above the 95th percentile. This finding, replicated across two nationally-representative samples, suggests that female sex protects girls from autistic impairments and that girls may require greater familial etiologic load to manifest the phenotype. It provides empirical support for the hypothesis of a female protective effect against autistic behavior and can be used to inform and interpret future gene finding efforts in autism spectrum disorders.

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