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Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome

Artikel i vetenskaplig tidskrift
Författare Anna Benrick
Manuel Maliqueo
Miao Sun
J. A. Villanueva
Y. Feng
Claes Ohlsson
A. J. Duleba
Elisabet Stener-Victorin
Publicerad i Evidence-Based Complementary and Alternative Medicine
Sidor Article ID 964070
ISSN 1741-427X
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor Article ID 964070
Språk en
Länkar dx.doi.org/10.1155/2013/964070
https://gup.ub.gu.se/file/107579
Ämnesord low-frequency electroacupuncture, sympathetic-nerve activity, theca-interstitial cells, adipose-tissue, skeletal-muscle, adipocyte, size, in-vitro, diet, women, fat
Ämneskategorier Klinisk medicin

Sammanfattning

Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with obesity and insulin resistance that often precedes the development of type-2 diabetes. Rats continuously exposed to dihydrotestosterone from prepuberty display typical reproductive and metabolic PCOS characteristics including anovulation, polycystic ovaries, insulin resistance, and obesity. Our aim was to investigate if resveratrol improves reproductive and metabolic functions in PCOS rats. The effect was compared to exercise. Control and PCOS rats were treated with vehicle or resveratrol (400 mg · kg−1 · day−1) for 5-6 weeks. Another group of PCOS rats received vehicle treatment and exercised for 5-6 weeks. Insulin sensitivity was determined by euglycemic-hyperinsulinemic clamp. The glucose infusion rate was lower in the PCOS-vehicle group compared to control-vehicle rats (). Exercise increased insulin sensitivity compared with PCOS-vehicle rats (), but resveratrol did not. Resveratrol treatment and exercise resulted in smaller adipocytes, upregulated estrogen-related receptor α gene expression in subcutaneous fat, and improved estrus cyclicity in the previously acyclic PCOS rats. Although resveratrol had positive effects on adiposity and cyclicity in a similar manner to exercise, resveratrol does not seem to be a good candidate for treating insulin resistance associated with PCOS because no improvement in insulin sensitivity was observed in PCOS rats on normal chow.

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