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Pacifier Cleaning Practices and Risk of Allergy Development.

Artikel i vetenskaplig tidskrift
Författare Bill Hesselmar
Fei Sjöberg
Robert Saalman
Nils Åberg
Ingegerd Adlerberth
Agnes E Wold
Publicerad i Pediatrics
Volym 131
Nummer/häfte 6
Sidor e1829 -e1837
ISSN 1098-4275
Publiceringsår 2013
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor e1829 -e1837
Språk en
Länkar dx.doi.org/10.1542/peds.2012-3345
Ämnesord allergy asthma child eczema infant microbiota pacifiers sensitization
Ämneskategorier Pediatrik

Sammanfattning

OBJECTIVE:Immune stimulation through exposure to commensal microbes may protect against allergy development. Oral microbes may be transferred from parents to infants via pacifiers. We investigated whether pacifier cleaning practices affected the risk of allergy development.METHODS:A birth-cohort of 184 infants was examined for clinical allergy and sensitization to airborne and food allergens at 18 and 36 months of age and, in addition, promptly on occurrence of symptoms. Pacifier use and pacifier cleaning practices were recorded during interviews with the parents when the children were 6 months old. The oral microbiota of the infants was characterized by analysis of saliva samples collected at 4 months of age.RESULTS:Children whose parents "cleaned" their pacifier by sucking it (n = 65) were less likely to have asthma (odds ratio [OR] 0.12; 95% confidence interval [CI] 0.01-0.99), eczema (OR 0.37; 95% CI 0.15-0.91), and sensitization (OR 0.37; 95% CI 0.10-1.27) at 18 months of age than children whose parents did not use this cleaning technique (n = 58). Protection against eczema remained at age 36 months (hazard ratio 0.51; P = .04). Vaginal delivery and parental pacifier sucking yielded independent and additive protective effects against eczema development. The salivary microbiota differed between children whose parents cleaned their pacifier by sucking it and children whose parents did not use this practice.CONCLUSIONS:Parental sucking of their infant's pacifier may reduce the risk of allergy development, possibly via immune stimulation by microbes transferred to the infant via the parent's saliva.

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