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Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease

Artikel i vetenskaplig tidskrift
Författare L. Pihlstrom
G. Axelsson
K. A. Bjornara
N. Dizdar
Camilla Fardell
L. Forsgren
Björn Holmberg
J. P. Larsen
J. Linder
Hans Nissbrandt
O. B. Tysnes
E. Ohman
E. Dietrichs
M. Toft
Publicerad i Neurobiology of Aging
Volym 34
Nummer/häfte 6
Sidor Article Number: 1708.e7
ISSN 0197-4580
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor Article Number: 1708.e7
Språk en
Länkar dx.doi.org/10.1016/j.neurobiolaging...
Ämnesord Parkinson's disease, GWAS, Genetic association study, Single-nucleotide polymorphism, risk-factors, identification, metaanalysis, population, variants, genetics, linkage, region, snca, hla, DC62/HIP1R, SYT11, GAK, STX1B, MCCC1/LAMP3, ACMSD, and FGF20). The more recently nominated
Ämneskategorier Geriatrik, Neurologi

Sammanfattning

enome-wide association studies have identified a number of susceptibility loci in sporadic Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded the list of proposed association signals. We performed a case-control replication study in a Scandinavian population, analyzing samples from 1345 unrelated PD patients and 1225 control subjects collected by collaborating centers in Norway and Sweden. Single-nucleotide polymorphisms representing 18 loci previously reported at genome-wide significance levels were genotyped, as well as 4 near-significant, suggestive, loci. We replicated 11 association signals at p < 0.05 (SNCA, STK39, MAPT, GPNMB, CCDC62/HIP1R, SYT11, GAK, STX1B, MCCC1/LAMP3, ACMSD, and FGF20). The more recently nominated susceptibility loci were well represented among our positive findings, including 3 which have not previously been validated in independent studies. Conversely, some of the more well-established loci failed to replicate. While future meta-analyses should corroborate disease associations further on the level of common markers, efforts to pinpoint functional variants and understand the biological implications of each risk locus in PD are also warranted.

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