Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Radixin expression in mic… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Radixin expression in microglia after cortical stroke lesion

Artikel i vetenskaplig tidskrift
Författare Åsa Persson
Ahmed Osman
Hayde Bolouri
Carina Mallard
Hans-Georg Kuhn
Publicerad i Glia
Volym 61
Nummer/häfte 5
Sidor 790-799
ISSN 0894-1491
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Sidor 790-799
Språk en
Länkar dx.doi.org/10.1002/glia.22473
Ämnesord ezrin, radixin, moesin, microglia activation, M1, M2 phenotype, ischemia, Olig2, focal cerebral-ischemia, adult subventricular zone, erm proteins, progenitor cells, brain-injury, rat-brain, tnf-alpha, neurogenesis, migration, proliferation
Ämneskategorier Neurologi, Neurofysiologi, Neurovetenskaper

Sammanfattning

Stroke induces extensive tissue remodeling, resulting in the activation of several cell types in the brain as well as recruitment of blood-borne leucocytes. Radixin is part of a cytoskeleton linker protein family with the ability to connect transmembrane proteins to the actin cytoskeleton, promoting cell functions involving a dynamic cytoskeleton such as morphological changes, cell division and migration which are common events of different cell types after stroke. In the healthy adult brain radixin is expressed in Olig2+ cells throughout the brain and in neural progenitor cells in the subventricular zone. In the current study, we detected a 2.5 fold increase in the number of radixin positive cells in the peri-infarct cortex two weeks after the induction of cortical stroke by photothrombosis. Similarly, the number of Olig2+ cells increased in the peri-infarct area after stroke; however, the number of radixin+/Olig2+ cells was unchanged. Neural progenitor cells maintained radixin expression on their route to the infarct. More surprising however, was the expression of radixin in activated microglia in the peri-infarct cortex. Seventy percent of Iba1+ cells expressed radixin after stroke, a population which was not present in the control brain. Furthermore, activation of radixin was predominantly detected in the peri-infarct region of oligodendrocyte progenitors and microglia. The specific location of radixin+ cells in the peri-infarct region and in microglia suggests a role for radixin in microglial activation after stroke.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?