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Adhesive microbeads for the targeting delivery of anticaries agents of vegetable origin

Artikel i vetenskaplig tidskrift
Författare B. Conti
B. Colzani
A. Papetti
D. Mascherpa
R. Dorati
I. Genta
C. Pruzzo
C. Signoretto
E. Zaura
Peter Lingström
I. Ofek
M. Wilson
D. A. Spratt
G. Gazzani
Publicerad i Food Chemistry
Volym 138
Nummer/häfte 2-3
Sidor 898-904
ISSN 0308-8146
Publiceringsår 2013
Publicerad vid Institutionen för odontologi
Sidor 898-904
Språk en
Länkar dx.doi.org/10.1016/j.foodchem.2012....
Ämnesord Functional foods, Anticaries, Antigingivitis, Microparticles, Bioadhesion, Chitosan, Alginate, drug-delivery, chitosan, polymers, systems, nanoparticles, alginate, cell
Ämneskategorier Cariologi, Biokemi och molekylärbiologi

Sammanfattning

The formulation of quinic acid, a food constituent demonstrating potential anticaries and antigingivitis properties, was investigated in an adhesive microparticulate delivery system with the goal of improving its effect by prolonging its residence time at the site of action. Alginate and chitosan were selected as mucoadhesive polymers. The microspheres were prepared by coacervation. Different types of alginates, polymers blends and crosslinking agent concentrations were considered and evaluated. The best results in terms of encapsulation efficiency, in vitro active agent release profile and in vitro adhesive properties, both to oral mucosa and to teeth surface, were obtained with a blend of Alginate Protanal LF200S: Alginate Protanal LF120LS 1:1.5 w/w, 0.1 M CaCl2, and chitosan coating, prepared by a one-step complex coacervation method. This microparticulate delivery system showed prolonged release of quinic acid, and could be used as an active component in chewing gums or mouthwashes for both caries and gingivitis prevention.

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