Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Amelioration of arthritis… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Amelioration of arthritis through mobilization of peptide-specific CD8(+) regulatory T cells

Artikel i vetenskaplig tidskrift
Författare J. W. Leavenworth
X. L. Tang
H. J. Kim
Xiaoyang Wang
H. Cantor
Publicerad i Journal of Clinical Investigation
Volym 123
Nummer/häfte 3
Sidor 1382-1389
ISSN 0021-9738
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 1382-1389
Språk en
Länkar dx.doi.org/10.1172/jci66938
Ämnesord collagen-induced arthritis, experimental autoimmune encephalomyelitis, rheumatoid-arthritis, endoplasmic-reticulum, self-tolerance, animal-models, ifn-gamma, il-15, disease, mice
Ämneskategorier Annan medicin och hälsovetenskap

Sammanfattning

Current therapies to treat autoimmune disease focus mainly on downstream targets of autoimmune responses, including effector cells and cytokines. A potentially more effective approach would entail targeting autoreactive T cells that initiate the disease cascade and break self tolerance. The murine MHC class Ib molecule Qa-1b (HLA-E in humans) exhibits limited polymorphisms and binds to 2 dominant self peptides: Hsp60p216 and Qdm. We found that peptide-induced expansion of tetramer-binding CD8+ Tregs that recognize Qa-1–Hsp60p216 but not Qa-1–Qdm strongly inhibited collagen-induced arthritis, an animal model of human rheumatoid arthritis. Perforin-dependent elimination of autoreactive follicular Th (TFH) and Th17 cells by CD8+ Tregs inhibited disease development. Infusion of in vitro–expanded CD8+ Tregs increased the efficacy of methotrexate treatment and halted disease progression after clinical onset, suggesting an alternative approach to this first-line treatment. Moreover, infusion of small numbers of Qa-1–Hsp60p216–specific CD8+ Tregs resulted in robust inhibition of autoimmune arthritis, confirming the inhibitory effects of Hsp60p216 peptide immunization. These results suggest that strategies designed to expand Qa-1–restricted (HLA-E–restricted), peptide-specific CD8+ Tregs represent a promising therapeutic approach to autoimmune disorders.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?