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Cardio-respiratory response to moderate chloral hydrate sedation in young lambs.

Artikel i vetenskaplig tidskrift
Författare Kenneth Sandberg
Stanley D Poole
Håkan W Sundell
Publicerad i Acta Paediatrica
Volym 102
Nummer/häfte 4
Sidor 391-396
ISSN 0803-5253
Publiceringsår 2013
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 391-396
Språk en
Länkar dx.doi.org/10.1111/apa.12151
Ämnesord Control of breathing;Distal airway function;Minute ventilation;Respiratory mechanics
Ämneskategorier Pediatrik

Sammanfattning

AIM: Chloral hydrate (CH) is the most commonly used sedative for medical procedures and lung function tests in infancy. The aim was to determine whether moderate CH sedation affects airway function, lung volume and ventilation. METHODS: Thirteen chronically instrumented 7- to 8-week-old lambs were studied both before and after CH sedation (50 mg/kg as intravenous bolus followed by 25 mg/kg/hour as continuous infusion). Nitrogen washout technique and lung mechanics analysis were used to assess functional residual capacity (FRC) and airway function. Moment analysis and lung clearance index were calculated as measures of gas mixing efficiency in distal airways. Respiratory rate, tidal volume, minute ventilation and indices of inspiratory drive were determined together with heart rate, blood pressure and oxygenation. RESULTS: No significant CH-induced changes were found for gas mixing efficiency, FRC or lung mechanics. Minute ventilation decreased slightly, but significantly, while indices of inspiratory drive remained unchanged. Heart rate increased significantly, but mean arterial blood pressure was unaffected. CONCLUSION: Moderate CH sedation did not significantly affect airway function or FRC. Although indices of inspiratory drive were not affected, minute ventilation decreased slightly. These findings indicate that reliable results can be obtained from lung function testing when CH is used for sedation.

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