Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

The antibody response in … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

The antibody response in breast-fed and non-breast-fed infants after artificial colonization of the intestine with Escherichia coli O83.

Artikel i vetenskaplig tidskrift
Författare R Lodinová-Zádníková
M Slavíková
H Tlaskalová-Hogenová
Ingegerd Adlerberth
Lars Åke Hanson
Agnes E Wold
Barbro Carlsson
C Svanborg
Lotta Mellander
Publicerad i Pediatric research
Volym 29
Nummer/häfte 4 Pt 1
Sidor 396-9
ISSN 0031-3998
Publiceringsår 1991
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 396-9
Språk en
Länkar dx.doi.org/10.1203/00006450-1991040...
Ämnesord Antibodies, Bacterial, biosynthesis, Breast Feeding, Escherichia coli, immunology, Escherichia coli Infections, immunology, prevention & control, Feces, microbiology, Female, Humans, Immunoglobulin A, biosynthesis, Infant, Infant Food, Infant, Newborn, Intestines, immunology, microbiology, Male
Ämneskategorier Pediatrik, Infektionsmedicin, Mikrobiologi inom det medicinska området, Immunologi inom det medicinska området

Sammanfattning

The local and systemic antibody response after oral administration of a nonenteropathogenic type 1 fimbriated Escherichia coli O83 strain was followed in nine breast-fed and eight formula-fed infants during their first 15 wk of life. Five breast-fed and six formula-fed infants were followed as controls. E. coli O83 was detected in the stools of colonized infants from d 2 after colonization and persisted in the intestine for up to 26 wk. The percentage of children successfully colonized with E. coli O83 was higher among breast-fed than among formula-fed colonized infants. Also, the O83 bacteria isolated from the breast-fed children had a higher capacity to attach to colonic epithelial cells of the HT-29 cell line than those isolated from bottle-fed infants. E. coli O83 IgA and IgM antibodies estimated by ELISA were significantly elevated in the saliva of colonized as compared with control infants 2-7 wk after colonization. IgA antibodies against O83 were also higher in the stool of colonized formula-fed infants than in formula-fed controls. The results suggest that the mucosal immune system of the newborn infant can be triggered early to produce specific antibodies against bacteria colonizing the intestine.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?