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High turnover rate of Escherichia coli strains in the intestinal flora of infants in Pakistan.

Artikel i vetenskaplig tidskrift
Författare Ingegerd Adlerberth
F Jalil
Barbro Carlsson
Lotta Mellander
Lars Åke Hanson
Peter Larsson
K Khalil
Agnes E Wold
Publicerad i Epidemiology and infection
Volym 121
Nummer/häfte 3
Sidor 587-98
ISSN 0950-2688
Publiceringsår 1998
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi
Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 587-98
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Diarrhea, etiology, Enterobacteriaceae, isolation & purification, Escherichia coli, classification, isolation & purification, Female, Humans, Infant, Infant Food, microbiology, Infant, Newborn, Longitudinal Studies, Male, Rectum, microbiology, Serotyping
Ämneskategorier Pediatrik, Mikrobiologi inom det medicinska området, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi


The Escherichia coli flora of infants in developed countries is dominated by one or a few strains which persist for prolonged periods of time, but no longitudinal studies have been performed in developing countries. To this end, we studied the rectal enterobacterial flora in 22 home-delivered Pakistani infants during their first 6 months of life. Three colonies were isolated and species typed on each of 11 sampling occasions. E. coli isolates were strain typed using electromorphic typing of cytoplasmic enzymes, and their O serogroups were determined. There was a very rapid turnover of enterobacterial strains in the rectal flora of individual infants. On average, 8.5 different E. coli strains were found per infant, and several biotypes of other enterobacteria. Less than 50% of the infants were colonized with E. coli from their mothers, but strains of maternal origin were four times more likely to persists in the infants' flora than other E. coli strains. Enterobacteria other than E. coli were always of non-maternal origin, and Enterobacter cloacae and Klebsiella pneumoniae biotypes recovered from contaminated feeds were later identified in the infants' rectal flora. An early colonization with klebsiella or enterobacter was significantly associated with diarrhoea during the neonatal period, although these bacteria were not likely to be the cause of the disease. The results suggest that poor hygienic conditions result in an unstable and diverse enterobacterial flora, which may influence infant health.

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