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Effects of long-term restricted feeding on plasma leptin, hepatic leptin expression and leptin receptor expression in juvenile Atlantic salmon (Salmo salar L.)

Artikel i vetenskaplig tidskrift
Författare S. Trombley
G. Maugars
Peter Kling
Björn Thrandur Björnsson
M. Schmitz
Publicerad i General and Comparative Endocrinology
Volym 175
Nummer/häfte 1
Sidor 92-99
ISSN 0016-6480
Publiceringsår 2012
Publicerad vid Institutionen för biologi och miljövetenskap
Sidor 92-99
Språk en
Länkar http://dx.doi.org/10.1016/j.ygcen....
Ämnesord leptin, leptin receptor, restricted feeding, atlantic salmon, teleost, goldfish carassius-auratus, food-intake, gene-expression, rainbow-trout, body-weight, genomic characterization, tissue distribution, takifugu-rubripes, adipose-tissue, messenger-rna
Ämneskategorier Biologiska vetenskaper

Sammanfattning

Leptin is a pleiotropic hormone and plays a key role in body weight regulation, energy homeostasis and lipid store utilization in mammals. In this study, we investigated the effect of feed-restriction on leptin genes (lepa1 and lepa2), leptin receptor (lepr) gene expression and plasma leptin levels in juvenile Atlantic salmon parr. Feed restriction was performed from late April to mid-June, in order to gain insight into the role of the leptin system in energy balance regulation and adiposity in juvenile salmon. A significant increase in lepa1 expression as well as higher levels of plasma leptin was found in feed-restricted fish in June compared to fully fed controls, while lepa2 gene expression decreased in both groups during the treatment period. Lepa2 was, however significantly higher in the feed-restricted group in June. Leptin receptor expression was up regulated during the period of enhanced growth and lipid deposition in the fully fed control, indicating a seasonal effect on the receptor expression in the brain. Both lepa1 and lepa2 genes very mainly expressed in the liver in juvenile salmon, while lepr was expressed in the brain but showed also considerable expression in various peripheral tissues. The study provides evidence that the leptin system is sensitive to the metabolic status of the fish as both season and restricted feeding affect lepa1 and lepa2 gene expression in the liver and brain leptin receptor expression, however, for lepa1 expression and leptin plasma level in an opposite way as that observed in the mammalian system. (C) 2011 Elsevier Inc. All rights reserved.

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