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Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease

Artikel i vetenskaplig tidskrift
Författare Anders Wallin
Annika Öhrfelt Olsson
Maria Bjerke
Publicerad i Journal of the Neurological Sciences
Volym 322
Nummer/häfte 1-2
Sidor 192-196
ISSN 0022-510X
Publiceringsår 2012
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 192-196
Språk en
Länkar dx.doi.org/10.1016/j.jns.2012.07.06...
Ämnesord Alzheimer's disease, Cerebral small vessel disease, Cerebrospinal fluid, Cognitive impairment, normal-pressure hydrocephalus, preclinical alzheimers-disease, cerebrospinal-fluid biomarkers, mild cognitive impairment, white-matter, lesions, vascular dementia, matrix metalloproteinases, binswanger-disease, basic-protein, brain
Ämneskategorier Neurologi

Sammanfattning

To be able to live a good, independent life cognitive functions need to be intact. Dementia, stroke and neuropsychiatric disorders are the major disorders underlying disability. Stroke is usually a consequence of an underlying vessel wall disease that has lasted for a longer period. This vessel wall disease is commonly silent or without prominent symptoms. Damage to the small penetrating arterioles of the brain, arteriolosclerosis, induced by aging and hypertension, as well as other factors such as diabetes and genetic vulnerability, plays an important role in the origin of white matter changes. The pathological vascular wall process leads to lumen constriction, impaired ability to change lumen diameter according to metabolic needs and possible ischemic-hypoxic tissue damage in the vulnerable vascular architectural terminal areas of the long penetrating arteries. The arteriolosclerotic blood vessels are associated with inflammation and remodelling of the extracellular matrix. Enzymes connected to this process have also been found to be involved in demyelination and blood brain barrier opening but also in the repair process of angiogenesis and neurogenesis. Biochemical changes reflecting these processes might be early indicators of small vessel disease and hence increase the knowledge about the disease characteristic mechanisms. Moreover, monitoring disease modifying treatment effects can be an important application for small vessel disease specific biochemical markers. (c) 2012 Elsevier B.V. All rights reserved.

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