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Carbonyl reductase mRNA abundance and enzymatic activity as potential biomarkers of oxidative stress in marine fish

Artikel i vetenskaplig tidskrift
Författare Eva Albertsson
A. Rad
Joachim Sturve
D. G. Joakim Larsson
Lars Förlin
Publicerad i Marine Environmental Research
Volym 80
Sidor 56-61
ISSN 0141-1136
Publiceringsår 2012
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för biologi och miljövetenskap
Sidor 56-61
Språk en
Länkar dx.doi.org/10.1016/j.marenvres.2012...
Ämnesord Carbonyl reductase, Biomarker, Biomonitoring, Eelpout, Oxidative stress, AhR-agonists, eelpout zoarces-viviparus, trout oncorhynchus-mykiss, rainbow-trout, 20-beta-hydroxysteroid dehydrogenase, gene-expression, coastal waters, nadph binding, pulp-mill, liver, quinone, rlin l, 1980, toxicology and applied pharmacology, v54, p420, ochaska hj, 1986, journal of biological chemistry, v261, p1372, naka m, 1992, journal of biological chemistry, v267, p13451
Ämneskategorier Biologiska vetenskaper

Sammanfattning

Carbonyl reductase (CBR) is an enzyme involved in protection from oxidative stress. In rainbow trout (Oncorhynchus mykiss), the hepatic mRNA abundance of the two isoforms (A and B) is increased after exposure to treated sewage effluents, as well as after exposure with beta-naphthoflavone (beta-NF) and the pro-oxidant paraquat In this study, we show that the same chemicals similarly increase the single known hepatic CBR mRNA level and CBR catalytic activity in the coastal living eelpout (Zoarces viviparus). Hepatic CBR mRNA abundance and catalytic activity were also compared between eelpout collected at contaminated and reference sites on the Swedish west coast, but no differences were observed. In conclusion, CBR is a potential biomarker candidate for monitoring the exposure and effects of AhR agonists and/or pro-oxidants in the marine environment, but more research is needed to investigate temporal regulation as well as dose dependency for different chemicals. The mRNA and enzymatic assays presented in this study provide two additional tools for researchers interested in expanding their biomarker battery. (c) 2012 Elsevier Ltd. All rights reserved.

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