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The pilosebaceous unit-a phthalate-induced pathway to skin sensitization

Artikel i vetenskaplig tidskrift
Författare Carl Simonsson
Anna-Lena Stenfeldt
Ann-Therese Karlberg
Marica B Ericson
Charlotte A Jonsson
Publicerad i Toxicology and Applied Pharmacology
Volym 264
Nummer/häfte 1
Sidor 114-120
ISSN 0041-008X
Publiceringsår 2012
Publicerad vid Institutionen för kemi och molekylärbiologi
Institutionen för fysik (GU)
Sidor 114-120
Språk en
Länkar dx.doi.org/10.1016/j.taap.2012.07.0...
Ämnesord Contact allergy, Dibutylphthalate, Two-photon-microscopy, Pilosebaceous unit, Local lymph node, allergic contact-dermatitis, human hair follicle, fluorescein, isothiocyanate, reactivity, capacity, delivery, afferent, system, cells
Ämneskategorier Molekylärbiologi

Sammanfattning

Allergic contact dermatitis (ACD) is caused by low-molecular weight compounds called haptens. It has been shown that the potency of haptens can depend on the formulation in which they are applied on the skin. Specifically the sensitization potency of isothiocyanates, a group of haptens which can be released from e.g. adhesive tapes and neoprene materials, increases with the presence of phthalates; however, the underlying mechanisms are not clear. A better understanding of the mechanisms governing the potency of haptens is important, e.g. to improve the risk assessment and the formulation of chemicals in consumer products. In this study we have explored phthalate-induced effects on the sensitization potency, skin distribution, and reactivity of fluorescent model isothiocyanate haptens using non-invasive two-photon microscopy to provide new insights regarding vehicle effects in ACD. The data presented in this paper indicate that the sensitization potency of isothiocyanates increases when applied in combination with dibutylphthalate due to a specific uptake via the pilosebaceous units. The results highlight the importance of shunt pathways when evaluating the bioavailability of skin sensitizers. The findings also indicate that vehicle-dependent hapten reactivity towards stratum corneum proteins regulates the bioavailability, and thus the potency, of skin sensitizers. (C) 2012 Elsevier Inc. All rights reserved.

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