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Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice

Artikel i vetenskaplig tidskrift
Författare Alexandra Stubelius
Anna S K Wilhelmson
J. A. Gogos
Åsa Tivesten
Ulrika Islander
Hans Carlsten
Publicerad i Immunobiology
Volym 217
Nummer/häfte 8
Sidor 751-760
ISSN 0171-2985
Publiceringsår 2012
Publicerad vid Wallenberglaboratoriet
Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Centre for Bone and Arthritis Research
Sidor 751-760
Språk en
Länkar dx.doi.org/10.1016/j.imbio.2012.04....
Ämnesord 2-Methoxyestradiol, Catechol-O-methyltransferase, Immune system, Estradiol metabolism, Sex-, estrogen-receptor specificity, collagen-induced arthritis, rheumatoid-arthritis, psychiatric-disorders, brain-function, breast-cancer, cell-activity, risk model, nk cells, estradiol
Ämneskategorier Immunologi inom det medicinska området

Sammanfattning

The enzyme catechol-O-methyltransferase (COMT) is part of the metabolic pathway of 17 beta-estradiol, converting 2-hydroxyestradiol to 2-methoxyestradiol. We recently showed that administration of the COMT product 2-methoxyestradiol has anti-inflammatory and anti-osteoporotic effects. We have now investigated whether COMT affects the immune system, by immunologically phenotyping COMT deficient (COMT-/-) mice. Immunoglobulin production, T lymphocyte proliferation, NK cell cytotoxicity and oxygen radical production were assessed. In male COMT-/--mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased. The NK cell population shifted toward less mature cells, leaving cytotoxic capacity unaffected. In COMT-/--females, a higher frequency of neutrophils was found but the oxygen radical production was unaltered. In conclusion, only minor changes of the immune system were seen in COMT deficient mice, and the changes were usually seen in males. This study provides clues into how COMT activity, and hence gender differences, affects the immune system. (c) 2012 Elsevier GmbH. All rights reserved.

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