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Infant B cell memory differentiation and early gut bacterial colonization.

Artikel i vetenskaplig tidskrift
Författare Anna-Carin Lundell
Viktor Björnsson
Annika Ljung
Margareta Ceder
Susanne Johansen
Gunhild Lindhagen
Carl-Johan Törnhage
Ingegerd Adlerberth
Agnes E Wold
Anna Rudin
Publicerad i Journal of immunology (Baltimore, Md. : 1950)
Volym 188
Nummer/häfte 9
Sidor 4315-22
ISSN 1550-6606
Publiceringsår 2012
Publicerad vid Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 4315-22
Språk en
Länkar dx.doi.org/10.4049/jimmunol.1103223
Ämnesord Adult, Aging, immunology, Antigens, CD, immunology, B-Lymphocytes, cytology, immunology, Bacteria, Anaerobic, immunology, Biological Agents, immunology, Cell Differentiation, physiology, Child Development, physiology, Child, Preschool, Cohort Studies, Escherichia coli, immunology, Feces, microbiology, Female, Humans, Immunologic Memory, physiology, Infant, Infant, Newborn, Intestines, immunology, microbiology, Male, Middle Aged, Sweden
Ämneskategorier Bakteriologi, Immunologi inom det medicinska området, Allergologi, Immunbiologi

Sammanfattning

Germ-free animal models have demonstrated that commensal bacterial colonization of the intestine induces B cell differentiation and activation. Whether colonization with particular bacterial species or groups is associated with B cell development during early childhood is not known. In a prospective newborn/infant cohort including 65 Swedish children, we examined the numbers and proportions of CD20(+), CD5(+), and CD27(+) B cells in blood samples obtained at several time points during the first 3 y of life using flow cytometry. Fecal samples were collected and cultured quantitatively for major facultative and anaerobic bacteria at 1, 2, 4, and 8 wk of life. We found that the numbers of CD20(+) B cells and CD5(+)CD20(+) B cells reached their highest levels at 4 mo, whereas CD20(+) B cells expressing the memory marker CD27 were most numerous at 18 and 36 mo of age. Using multivariate analysis, we show that early colonization with Escherichia coli and bifidobacteria were associated with higher numbers of CD20(+) B cells that expressed the memory marker CD27 at 4 and 18 mo of age. In contrast, we were unable to demonstrate any relation between bacterial colonization pattern and numbers of CD20(+) or CD5(+)CD20(+) B cells. These results suggest that the intestinal bacterial colonization pattern may affect the B cell maturation also in humans, and that an early gut microbiota including E. coli and bifidobacteria might promote this maturation.

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