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Subsets of migrating intestinal dendritic cells.

Forskningsöversiktsartikel
Författare Simon Milling
Ulf Yrlid
Vuk Cerovic
Gordon MacPherson
Publicerad i Immunological reviews
Volym 234
Nummer/häfte 1
Sidor 259-67
ISSN 1600-065X
Publiceringsår 2010
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 259-67
Språk en
Länkar dx.doi.org/10.1111/j.0105-2896.2009...
Ämnesord Animals, Antigens, CD, immunology, Antigens, CD11b, immunology, Antigens, CD8, immunology, Cell Movement, Dendritic Cells, immunology, Humans, Integrin alpha Chains, immunology, Intestinal Mucosa, cytology, immunology, Lymph, cytology, immunology, Lymph Nodes, cytology, immunology, Mice, Peyer's Patches, cytology, immunology, Phenotype, Rats, Signal Transduction
Ämneskategorier Immunbiologi

Sammanfattning

Dendritic cells (DCs) in the intestine are heterogeneous. Phenotypically different populations of conventional DCs have been identified in the intestinal lamina propria, Peyer's patches, and in the draining mesenteric lymph nodes, to which these DCs constitutively migrate. Markers used to identify these populations include major histocompatibility complex class II, CD11c, CD8 alpha, CD11b, and CD103. Extensive studies in rats, summarized here, which involved collection of migrating DCs by thoracic duct cannulation after mesenteric lymphadenectomy, have clearly demonstrated that the subsets of migrating intestinal lymph DCs have different functional properties. The subsets might play different roles in the induction of oral tolerance and in driving systemic immune responses after vaccination or intestinal stimulation with Toll-like receptor ligands. The use of these surgical techniques allows investigation of the functions of purified subsets of migrating DCs. However, in the rat, these studies are limited by the range of available reagents and are difficult to compare with data from other species in this fast-moving field. Recent refinements have enabled the collection of migrating intestinal DCs from mice; our initial results are described here. We believe that these studies will generate exciting data and have the potential to resolve important questions about the functions of migrating intestinal DC subsets.

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