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Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury.

Artikel i vetenskaplig tidskrift
Författare Johan Ljungqvist
Daniel Nilsson
Maria Ljungberg
Ann Sörbo
Eva Esbjörnsson
Catherine Eriksson-Ritzén
Thomas Skoglund
Publicerad i Brain injury
Volym 25
Nummer/häfte 4
Sidor 370-378
ISSN 1362-301X
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor 370-378
Språk en
Länkar dx.doi.org/10.3109/02699052.2011.55...
Ämnesord Adult, Corpus Callosum, injuries, physiopathology, Diffuse Axonal Injury, diagnosis, physiopathology, Diffusion Magnetic Resonance Imaging, methods, Female, Glasgow Outcome Scale, Humans, Male, Middle Aged, Neural Pathways, physiology, Neuropsychological Tests, Prospective Studies, Young Adult
Ämneskategorier Radiofysik, Fysiologi

Sammanfattning

Background: Magnetic resonance diffusion tensor imaging (MR-DTI) is used increasingly to detect diffuse axonal injury (DAI) after traumatic brain injury (TBI). Primary objective: The primary objective was to investigate the changes in the diffusion properties of the corpus callosum in the acute phase and 6 months after TBI and to examine the correlation between DTI parameters and clinical outcome. Research design: Longitudinal prospective study. Methods and procedures: MR-DTI was performed in eight patients with suspected DAI within 11 days and at 6 months post-injury. Six controls were also examined. Fractional anisotropy (FA), trace and parallel and perpendicular diffusivity of the corpus callosum were analysed. The main outcome was the extended Glasgow Outcome Scale score, assessed at 6 months. Main outcomes and results: A significant reduction in FA in the corpus callosum was seen in the acute phase in patients compared with the healthy controls. There was no significant change in the parallel or perpendicular eigenvalues or trace. At 6 months, a significant reduction in FA and a significant increase in trace and perpendicular eigenvalues were noticed compared with controls. Conclusions: The diffusion properties of the corpus callosum correlated with clinical outcome in this longitudinal investigation.

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