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Bone tissue reactions to biomimetic ion-substituted apatite surfaces on titanium implants.

Artikel i vetenskaplig tidskrift
Författare Ahmed Ballo
Wei Xia
Anders Palmquist
Carl Lindahl
Lena Emanuelsson
Jukka Lausmaa
Håkan Engqvist
Peter Thomsen
Publicerad i Journal of the Royal Society Interface
Volym 9
Nummer/häfte 72
Sidor 1615-24
ISSN 1742-5662
Publiceringsår 2012
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 1615-24
Språk en
Länkar dx.doi.org/10.1098/rsif.2011.0808
Ämneskategorier Biomaterialvetenskap

Sammanfattning

The aim of this study was to evaluate the bone tissue response to strontium- and silicon-substituted apatite (Sr-HA and Si-HA) modified titanium (Ti) implants. Sr-HA, Si-HA and HA were grown on thermally oxidized Ti implants by a biomimetic process. Oxidized implants were used as controls. Surface properties, i.e. chemical composition, surface thickness, morphology/pore characteristics, crystal structure and roughness, were characterized with various analytical techniques. The implants were inserted in rat tibiae and block biopsies were prepared for histology, histomorphometry and scanning electron microscopy analysis. Histologically, new bone formed on all implant surfaces. The bone was deposited directly onto the Sr-HA and Si-HA implants without any intervening soft tissue. The statistical analysis showed significant higher amount of bone-implant contact (BIC) for the Si-doped HA modification (P = 0.030), whereas significant higher bone area (BA) for the Sr-doped HA modification (P = 0.034), when compared with the non-doped HA modification. The differences were most pronounced at the early time point. The healing time had a significant impact for both BA and BIC (P < 0.001). The present results show that biomimetically prepared Si-HA and Sr-HA on Ti implants provided bioactivity and promoted early bone formation.

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