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On the formation of fibro… - Göteborgs universitet Till startsida
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On the formation of fibrous capsule and fluid space around machined and porous blood plasma clot coated titanium.

Artikel i vetenskaplig tidskrift
Författare E Jansson
Mia Källtorp
Anna Johansson
Pentti Tengvall
Peter Thomsen
Publicerad i Journal of materials science. Materials in medicine
Volym 12
Nummer/häfte 10-12
Sidor 1019-24
ISSN 0957-4530
Publiceringsår 2001
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap
Institutionen för anatomi och cellbiologi
Sidor 1019-24
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Biomaterialvetenskap, Klinisk medicin

Sammanfattning

Machined and machined submicron porous titanium, with and without a thin blood plasma coating (100 nm), were implanted for 7 or 28 days in subcutaneous pockets on the back of the rat. After explantation the specimens were analyzed by light microscopy with respect to thickness of the fibrous capsule, the fluid space width between implants and fibrous capsule, and formation of blood vessels. The results at 7 days indicate a thinnest fluid space for the plasma clot coated porous titanium surface, and the spaces vanished at the light microscopic level after 28 days outside all the analyzed surfaces. The thickness of the fibrous capsule increased outside the different surfaces at 7-28 days, and in this respect no significant differences were observed between the different surfaces at any time. Analysis of neovascularization showed that the number of vessels and proportion of vessels in the fibrous capsule increased with time at all surfaces, except machined Ti where the number instead decreased from 7 to 28 days. The average distance between the blood vessels and the fluid space increased with time for all types of surfaces. The results in the present study indicate that the healing process around titanium can be modulated by porosity and thin pre-prepared plasma coatings.

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