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The effects of fractions from shiitake mushroom on composition and cariogenicity of dental plaque microcosms in an in vitro caries model.

Artikel i vetenskaplig tidskrift
Författare Egija Zaura
Mark J Buijs
Michel A Hoogenkamp
Lena Ciric
Adele Papetti
Caterina Signoretto
Monica Stauder
Peter Lingström
Jonathan Pratten
David A Spratt
Michael Wilson
Publicerad i Journal of biomedicine & biotechnology
Volym 2011
Sidor 135034
ISSN 1110-7251
Publiceringsår 2011
Publicerad vid Institutionen för odontologi
Sidor 135034
Språk en
Länkar dx.doi.org/10.1155/2011/135034
Ämnesord Animals, Biofilms, drug effects, Cariostatic Agents, pharmacology, Cattle, Dental Caries, prevention & control, Dental Plaque, metabolism, microbiology, Dentin, chemistry, drug effects, Models, Biological, Molecular Weight, Saliva, microbiology, Shiitake Mushrooms, chemistry, Statistics, Nonparametric
Ämneskategorier Cariologi

Sammanfattning

The aim of the current study was to investigate the anticariogenic potential of the (sub)fractions obtained from the edible mushroom shiitake (Lentinula edodes) in in vitro caries model. We used a modified constant depth film fermentor (CDFF) with pooled saliva as the inoculum and bovine dentin as a substratum. The test compounds were low molecular weight fraction (MLMW) of the shiitake extract and subfractions 4 and 5 (SF4 and SF5) of this fraction. Chlorhexidine (CHX) and water served as a positive and a negative control, respectively. Dentin mineral loss was quantified (TMR), microbial shifts within the microcosms were determined (qPCR), and the acidogenicity of the microcosms was assessed (CIA). From the compounds tested, the SF4 of shiitake showed strong inhibiting effect on dentin demineralization and induced microbial shifts that could be associated with oral health. The acid producing potential was increased, suggesting uncoupling of the glycolysis of the microbiota by the exposure to SF4. In conclusion, the results suggest that SF4 of shiitake has an anticariogenic potential.

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