Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Association of Sirtuin 1 … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity.

Artikel i vetenskaplig tidskrift
Författare Stephen J Clark
Mario Falchi
Bob Olsson
Peter Jacobson
Stéphane Cauchi
Beverley Balkau
Michel Marre
Olivier Lantieri
Johanna Andersson
Margareta Jernås
Timothy J Aitman
Sylvia Richardson
Lars Sjöström
Hang Y Wong
Lena M S Carlsson
Philippe Froguel
Andrew J Walley
Publicerad i Obesity
Volym 20
Nummer/häfte 1
Sidor 178-85
ISSN 1930-7381
Publiceringsår 2012
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 178-85
Språk en
Länkar dx.doi.org/10.1038/oby.2011.200
Ämnesord Obesity, BMI, sirtuin 1, SNP, gene expression
Ämneskategorier Molekylärbiologi, Genetik

Sammanfattning

Recent studies have reported associations of sirtuin 1 (SIRT1) single nucleotide polymorphisms (SNPs) to both obesity and BMI. This study was designed to investigate association between SIRT1 SNPs, SIRT1 gene expression and obesity. Case-control analyses were performed using 1,533 obese subjects (896 adults, BMI >40 kg/m(2) and 637 children, BMI >97th percentile for age and sex) and 1,237 nonobese controls, all French Caucasians. Two SNPs (in high linkage disequilibrium (LD), r(2) = 0.96) were significantly associated with adult obesity, rs33957861 (P value = 0.003, odds ratio (OR) = 0.75, confidence interval (CI) = 0.61-0.92) and rs11599176 (P value: 0.006, OR = 0.74, CI = 0.61-0.90). Expression of SIRT1 mRNA was measured in BMI-discordant siblings from 154 Swedish families. Transcript expression was significantly correlated to BMI in the lean siblings (r(2) = 0.13, P value = 3.36 × 10(-7)) and lower SIRT1 expression was associated with obesity (P value = 1.56 × 10(-35)). There was also an association between four SNPs (rs11599176, rs12413112, rs33957861, and rs35689145) and BMI (P values: 4 × 10(-4), 6 × 10(-4), 4 × 10(-4), and 2 × 10(-3)) with the rare allele associated with a lower BMI. However, no SNP was associated with SIRT1 transcript expression level. In summary, both SNPs and SIRT1 gene expression are associated with severe obesity.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?