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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.

Artikel i vetenskaplig tidskrift
Författare Tuomas O Kilpeläinen
Lu Qi
Soren Brage
Stephen J Sharp
Emily Sonestedt
Ellen Demerath
Tariq Ahmad
Samia Mora
Marika Kaakinen
Camilla Helene Sandholt
Christina Holzapfel
Christine S Autenrieth
Elina Hyppönen
Stéphane Cauchi
Meian He
Zoltan Kutalik
Meena Kumari
Alena Stančáková
Karina Meidtner
Beverley Balkau
Jonathan T Tan
Massimo Mangino
Nicholas J Timpson
Yiqing Song
M Carola Zillikens
Kathleen A Jablonski
Melissa E Garcia
Stefan Johansson
Jennifer L Bragg-Gresham
Ying Wu
Jana V van Vliet-Ostaptchouk
N Charlotte Onland-Moret
Esther Zimmermann
Natalia V Rivera
Toshiko Tanaka
Heather M Stringham
Günther Silbernagel
Stavroula Kanoni
Mary F Feitosa
Soren Snitker
Jonatan R Ruiz
Jeffery Metter
Maria Teresa Martinez Larrad
Mustafa Atalay
Maarit Hakanen
Najaf Amin
Christine Cavalcanti-Proença
Anders Grøntved
Göran Hallmans
John-Olov Jansson
Johanna Kuusisto
Mika Kähönen
Pamela L Lutsey
John J Nolan
Luigi Palla
Oluf Pedersen
Louis Pérusse
Frida Renström
Robert A Scott
Dmitry Shungin
Ulla Sovio
Tuija H Tammelin
Tapani Rönnemaa
Timo A Lakka
Matti Uusitupa
Manuel Serrano Rios
Luigi Ferrucci
Claude Bouchard
Aline Meirhaeghe
Mao Fu
Mark Walker
Ingrid B Borecki
George V Dedoussis
Andreas Fritsche
Claes Ohlsson
Michael Boehnke
Stefania Bandinelli
Cornelia M van Duijn
Shah Ebrahim
Debbie A Lawlor
Vilmundur Gudnason
Tamara B Harris
Thorkild I A Sørensen
Karen L Mohlke
Albert Hofman
André G Uitterlinden
Jaakko Tuomilehto
Terho Lehtimäki
Olli Raitakari
Bo Isomaa
Pål R Njølstad
Jose C Florez
Simin Liu
Andy Ness
Timothy D Spector
E Shyong Tai
Philippe Froguel
Heiner Boeing
Markku Laakso
Michael Marmot
Sven Bergmann
Chris Power
Kay-Tee Khaw
Daniel Chasman
Paul Ridker
Torben Hansen
Keri L Monda
Thomas Illig
Marjo-Riitta Järvelin
Nicholas J Wareham
Frank B Hu
Leif C Groop
Marju Orho-Melander
Ulf Ekelund
Paul W Franks
Ruth J F Loos
Publicerad i PLoS medicine
Volym 8
Nummer/häfte 11
Sidor e1001116
ISSN 1549-1676
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin
Sidor e1001116
Språk en
Länkar dx.doi.org/10.1371/journal.pmed.100...
Ämneskategorier Endokrinologi, Invärtesmedicin

Sammanfattning

BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction)  = 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio  = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio  = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.

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