Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Autism spectrum disorders… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Autism spectrum disorders and autistic like traits: similar etiology in the extreme end and the normal variation.

Artikel i vetenskaplig tidskrift
Författare Sebastian Lundström
Zheng Chang
Maria Råstam
Christopher Gillberg
Henrik Larsson
Henrik Anckarsäter
Paul Lichtenstein
Publicerad i Archives of General Psychiatry
Volym 69
Nummer/häfte 1
Sidor 46-52
ISSN 0003-990X
Publiceringsår 2012
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Gillbergcentrum
Centrum för etik, juridik och mental hälsa
Sidor 46-52
Språk en
Länkar dx.doi.org/10.1001/archgenpsychiatr...
Ämnesord Child, Child Development Disorders, Pervasive, Epidemiology, Genetics, Psychology, Cohort Studies, Diseases in Twins, Genetics, Psychology, Female, Health Surveys, Humans, Interview, Psychological, Male, Sweden, Epidemiology, Twins, Genetics, Psychology
Ämneskategorier Barn- och ungdomspsykiatri

Sammanfattning

CONTEXT: Autism spectrum disorders (ASDs) have been suggested to represent the extreme end of a normal distribution of autisticlike traits (ALTs). However, the evidence of this notion is inconclusive. OBJECTIVE: To study whether there are similar genetic and/or environmental etiologies behind ASDs and ALTs. DESIGN: A nationwide twin study. PARTICIPANTS: Consenting parents of all Swedish twins aged 9 and 12 years, born between July 1, 1992, and December 31, 2001 (n = 19 208), were interviewed by telephone to screen for child psychiatric conditions, including ASDs. MAIN OUTCOME MEASURES: Two validated cutoffs for ASDs, 2 cutoffs encompassing the normal variation, and 1 continuous measure of ALTs were used with DeFries-Fulker extreme-end analyses and standard twin study methods. RESULTS: We discerned a strong correlation between the 4 cutoffs and the full variation of ALTs. The correlation was primarily affected by genes. We also found that the heritability for the 4 cutoffs was similar. CONCLUSION: We demonstrate an etiological similarity between ASDs and ALTs in the normal variation and, with results from previous studies, our data suggest that ASDs and ALTs are etiologically linked.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?