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Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment.

Artikel i vetenskaplig tidskrift
Författare Kaiming Huo
Zhan Zhang
Dehua Zhao
Hezhou Li
Jun Wang
Xinxia Wang
Hongqi Feng
Xiaoyang Wang
Changlian Zhu
Publicerad i Endocrine journal
Volym 58
Nummer/häfte 5
Sidor 355-61
ISSN 0918-8959
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor 355-61
Språk en
Länkar www.ncbi.nlm.nih.gov/pubmed/2146769...
Ämnesord Congenital hypothyroidism; Neonatal screening; Developmental quotient
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Neurodevelopment in children with congenital hypothyroidism who receive early treatment is generally good. However, subtle neurological deficits still exist in some patients. The aim of this investigation was to evaluate factors that may influence neurodevelopmental outcome in congenital hypothyroidism patients. The developmental quotient (DQ) of 155 children with congenital hypothyroidism was evaluated at 24 months of age, using Gesell Developmental Schedules (GDS), and compared with that of 310 healthy controls. Mean DQ scores in congenital hypothyroidism patients were 7.5 points lower for adaptive behavior than in control patients (p < 0.01). Patients with severe congenital hypothyroidism had the lowest DQ scores compared with two other congenital hypothyroidism subgroups and controls (p < 0.01). Children with congenital hypothyroidism who also had a low level of serum T(4) at diagnosis or exhibited a longer thyroid stimulating hormone (TSH) normalization time had lower adaptive behavior scores (p < 0.0003). Bivariate correlation and multiple regression analyses found that the severity of congenital hypothyroidism and parental socioeconomic status correlated with DQ scores. TSH normalization time was negatively related to adaptive behavior scores (p < 0.01). Neurodevelopmental deficits in children with congenital hypothyroidism correlate with the severity of congenital hypothyroidism, TSH normalization time, and parental socioeconomic status.

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