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Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease

Artikel i vetenskaplig tidskrift
Författare Annika Öhrfelt Olsson
Ulf Andreasson
Adam Simon
Henrik Zetterberg
Åke Edman
William Potter
Daniel Holder
Viswanath Devanarayan
Jeffrey Seeburger
David A Smith
Kaj Blennow
Anders Wallin
Publicerad i Dementia and Geriatric Cognitive Disorders Extra
Volym 1
Nummer/häfte 1
Sidor 31-42
ISSN 1664-5464
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 31-42
Språk en
Länkar dx.doi.org/10.1159/000323417
Ämnesord Alzheimer’s disease, Biomarkers, Cerebrospinal fluid, Mild cognitive impairment, Vascular dementia
Ämneskategorier Psykiatri

Sammanfattning

Background: Novel biomarkers are important for identifying as well as differentiating subcortical vascular dementia (SVD) and Alzheimer’s disease (AD) at an early stage in the disease process. Methods: In two independent cohorts, a multiplex immunoassay was utilized to analyze 90 proteins in cerebrospinal fluid (CSF) samples from dementia patients and patients at risk of developing dementia (mild cognitive impairment). Results: The levels of several CSF proteins were increased in SVD and its incipient state, and in moderate-to-severe AD compared with the control group. In contrast, some CSF proteins were altered in AD, but not in SVD. The levels of heart-type fatty acid binding protein (H-FABP) were consistently increased in all groups with dementia but only in some of their incipient states. Conclusions: In summary, these results support the notion that SVD and AD are driven by different pathophysiological mechanisms reflected in the CSF protein profile and that H-FABP in CSF is a general marker of neurodegeneration

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