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Autistic-like traits and their association with mental health problems in two nationwide twin cohorts of children and adults.

Artikel i vetenskaplig tidskrift
Författare Sebastian Lundström
Zheng Chang
Nora Kerekes
Clara H Gumpert
Maria Råstam
Christopher Gillberg
Paul Lichtenstein
Henrik Anckarsäter
Publicerad i Psychological Medicine
Volym 41
Nummer/häfte 11
Sidor 2423-2433
ISSN 0033-2917
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Gillbergcentrum
Sidor 2423-2433
Språk en
Länkar dx.doi.org/10.1017/S003329171100037...
Ämnesord Adolescent, Adult, Anxiety Disorders, Epidemiology, Attention Deficit Disorder with Hyperactivity, Epidemiology, Child, Child Development Disorders, Pervasive, Epidemiology, Genetics, Cohort Studies, Comorbidity, Depressive Disorder, Epidemiology, Diseases in Twins, Epidemiology, Genetics, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Epidemiology, Humans, Male, Mental Disorders, Epidemiology, Risk, Substance-Related Disorders, Epidemiology, Sweden, Epidemiology
Ämneskategorier Barn- och ungdomspsykiatri

Sammanfattning

Background. Autistic-like traits (ALTs), that is restrictions in intuitive social interaction, communication and flexibility of interests and behaviors, were studied in two population-based Swedish twin studies, one in children and one in adults : (1) to examine whether the variability in ALTs is a meaningful risk factor for concomitant attention deficit hyperactivity disorder (ADHD), anxiety, conduct problems, depression and substance abuse, and (2) to assess whether common genetic and environmental susceptibilities can help to explain co-existence of ALTs and traits associated with such concomitant problems. Method. Two nationwide twin cohorts from Sweden (consisting of 11 222 children and 18 349 adults) were assessed by DSM-based symptom algorithms for autism. The twins were divided into six groups based on their degree of ALTs and the risk for concomitant mental health problems was calculated for each group. Genetic and environmental susceptibilities common to ALTs and the other problem types were examined using bivariate twin modeling. Results. In both cohorts, even the lowest degree of ALTs increased the risk for all other types of mental health problems, and these risk estimates increased monotonically with the number of ALTs. For all conditions, common genetic and environmental factors could be discerned. Overall, the phenotypic correlation between ALTs and the traits examined were less pronounced in adulthood than in childhood and less affected by genetic compared with environmental factors. Conclusions. Even low-grade ALTs are relevant to clinical psychiatry as they increase the risk for several heterotypical mental health problems. The association is influenced partly by common genetic and environmental susceptibilities. Attention to co-existing ALTs is warranted in research on a wide range of mental disorders.

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