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Inflammatory cytokines in gastric fluid at birth and the development of bronchopulmonary dysplasia

Artikel i vetenskaplig tidskrift
Författare H Stichel
Erica Bäckström
Ola Hafström
Staffan Nilsson
Urpo Lappalainen
Kristina Bry
Publicerad i Acta paediatrica (Oslo, Norway : 1992)
Volym 100
Nummer/häfte 9
Sidor 1206-1212
ISSN 1651-2227
Publiceringsår 2011
Publicerad vid Institutionen för matematiska vetenskaper, matematisk statistik
Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 1206-1212
Språk en
Länkar dx.doi.org/10.1111/j.1651-2227.2011...
Ämnesord Chorioamnionitis, Cytokines, Inflammation, Neonatal lung disease, Preterm birth
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Aim:  To assess whether the levels of inflammatory and anti-inflammatory proteins in gastric fluid of premature infants shortly after birth are associated with the development of bronchopulmonary dysplasia (BPD). Methods:  Gastric fluid retrieved within 1 h of birth of premature infants (gestational age <29 weeks) was analysed for interleukin (IL)-8, growth-related oncogene (Gro)-α, epithelial cell-derived neutrophil-activating peptide (ENA)-78, IL-1β and Clara cell secretory protein with ELISA. Results:  Of 51 enrolled infants, 86% had BPD. Of these, 54% had mild BPD, 30% had moderate BPD and 16% had severe BPD. Clinical chorioamnionitis was associated with high levels of IL-8, Gro-α, Epithelial cell-derived neutrophil-activating peptide-78 (ENA-78) and IL-1β in gastric fluid. Gastric fluid levels of IL-8, Gro-α, ENA-78 and IL-1β were higher in infants with moderate or severe BPD than in those with no or mild BPD. Ligation of the patent ductus arteriosus was associated with the development of moderate or severe BPD. These associations were no longer significant after adjustment for gestational age. Conclusion:  The levels of inflammatory mediators in gastric fluid samples retrieved soon after birth from intubated or nonintubated infants can be used to assess the infants' perinatal exposure to inflammatory mediators and its association with neonatal outcome.

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