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Piglet model for studying esophageal regrowth after resection and interposition of a silicone stented small intestinal submucosa tube.

Artikel i vetenskaplig tidskrift
Författare Linus Jönsson
Vladimir Gatzinsky
Eva Jennische
C Johanson
Ulf Nannmark
Lars-Göran Friberg
Publicerad i European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
Volym 46
Nummer/häfte 4
Sidor 169-79
ISSN 1421-9921
Publiceringsår 2011
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Institutionen för kliniska vetenskaper, Avdelningen för radiologi
Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Institutionen för kliniska vetenskaper
Sidor 169-79
Språk en
Länkar dx.doi.org/10.1159/000324401
Ämneskategorier Kirurgi

Sammanfattning

Purpose: To investigate the use and subsequent healing of a silicone stented small intestinal submucosa (SIS) tube as a full-circumference replacement following surgical resection of the esophagus in piglets. Material and Methods: Three centimeters of the intrathoracic esophagus was replaced with a silicone stented SIS tube (Cook Medical) in 6 growing piglets. The esophageal stent was retained for 4 weeks. Esophageal dilations were performed, if needed, after stent removal. Results: The piglets were sacrificed 1-17 weeks after surgery. Recurrent dilations were needed after stent removal. Histology showed that the gap between the resection margins was filled with new loose connective tissue consisting of fibroblasts and few inflammatory cells. In this tissue, intense angiogenesis was seen at the early time points, which then gave way to the proliferation of immature-looking smooth-muscle-like cells in the submucosa, which appeared to stem from the pericytes of the ingrowing capillaries. Conclusions: Through using a stented SIS tube as a circumferential esophageal replacement in a piglet model, this study suggests that pericytes from ingrowing capillaries may play a role in the remodeling of the SIS mesh. It remains to be seen if this process gives a favorable end result because stricture formation after stent removal remains a problem.

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