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Tramadol-induced oral dryness and pilocarpine treatment: Effects on total protein and IgA.

Artikel i vetenskaplig tidskrift
Författare H Looström
S Akerman
D Ericson
Gunnar Tobin
B Götrick
Publicerad i Archives of oral biology
Volym 56
Nummer/häfte 4
Sidor 395-400
ISSN 1879-1506
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 395-400
Språk en
Länkar dx.doi.org/10.1016/j.archoralbio.20...
Ämneskategorier Farmakologi och toxikologi

Sammanfattning

Pilocarpine induces a profuse flow of saliva, and it may re-establish saliva production in cases of drug-induced oral dryness. The aim of the study (a sub-study to the previous trial investigating the pilocarpine fluid effects in individuals suffering from drug-induced dry mouth) was to search for saliva quality changes induced by the treatments. Sixty-five individuals were enrolled in a randomized, double-blind, placebo-controlled trial. The subjects received tramadol to induce oral dryness. Secretion rate was measured before and after tramadol, and then after pilocarpine, placebo, or no treatment. All saliva was analyzed for its protein and IgA content in the pilocarpine (n=15) and placebo groups (n=12). At baseline, the flow of saliva was 0.47±0.05ml/min, the protein output 0.17±0.2mg/min and the IgA output 0.022±0.002mg/min. After tramadol treatment (50mg 3×/day over two days), the flow was reduced by 64%, protein output by 52% and the IgA output by 38%. While placebo treatment did not affect any of the variables, the flow was 120%, the protein output 193% and the IgA output 83% of the baseline characteristics after pilocarpine treatment (5mg). Thus, the pilocarpine-induced increase in the flow rate in the state of tramadol-induced oral dryness results in saliva with a well preserved protein concentration but with a decrease in IgA concentration. However, compared to baseline, there was neither a decrease in output nor in concentration of IgA.

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