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Increased frequency of intestinal Escherichia coli carrying genes for S fimbriae and haemolysin in IgA-deficient individuals.

Artikel i vetenskaplig tidskrift
Författare Vanda Friman
Forough Nowrouzian
Ingegerd Adlerberth
Agnes E Wold
Publicerad i Microbial pathogenesis
Volym 32
Nummer/häfte 1
Sidor 35-42
ISSN 0882-4010
Publiceringsår 2002
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar
Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi
Sidor 35-42
Språk en
Länkar dx.doi.org/10.1006/mpat.2001.0477
Ämnesord Adolescent, Adult, Aged, Escherichia coli, genetics, isolation & purification, metabolism, pathogenicity, Escherichia coli Infections, microbiology, Female, Fimbriae, Bacterial, genetics, metabolism, Hemolysin Proteins, genetics, metabolism, Humans, IgA Deficiency, complications, microbiology, Intestine, Large, microbiology, Male, Middle Aged, Polymerase Chain Reaction, Virulence, genetics
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Persons with selective IgA deficiency carry an increased risk of coeliac disease, inflammatory bowel disease and perhaps also gastrointestinal malignancies. Inflammatory bowel disease is associated with an increased carriage of adherent and haemolytic Escherichia coli in the intestinal microflora. This study was designed to investigate whether IgA-deficient individuals carry E. coli with virulence-associated properties in their gut flora. The last free-lying colony of E. coli isolates obtained from rectal flora of 25 IgA-deficient and 20 age-matched control individuals was assayed by multiplex PCR for genes for the following adhesins or virulence determinants: P, type 1 and S fimbriae, Dr haemagglutinin, haemolysin, aerobactin and the capsular types K1 and K5. E. coli strains from the intestinal microflora of IgA-deficient individuals more often had the gene for S fimbriae (36% of the strains compared with 0% in control subjects, P=0.003) as well as for haemolysin (40 vs 10% of the strains, P=0.040). IgA-deficient individuals had instead lower frequencies of E. coli carrying genes for type 1 fimbriae in their microflora (68 vs 90%, P=0.14). The results suggest that IgA-deficient individuals carry an increased frequency of E. coli with potentially inflammatogenic properties in their microflora, which may contribute to the development of gastrointestinal disorders such as inflammatory bowel diseases.

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