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Campylobacter jejuni colonization in wild birds: results from an infection experiment.

Artikel i vetenskaplig tidskrift
Författare Jonas Waldenström
Diana Axelsson-Olsson
Björn Olsen
Dennis Hasselquist
Petra Griekspoor
Lena Jansson
Susann Teneberg
Lovisa Svensson
Patrik Ellström
Publicerad i PloS one
Volym 5
Nummer/häfte 2
Sidor e9082
ISSN 1932-6203
Publiceringsår 2010
Publicerad vid Institutionen för biomedicin
Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor e9082
Språk en
Länkar dx.doi.org/10.1371/journal.pone.000...
Ämnesord Animals, Animals, Wild, Antibodies, Bacterial, blood, immunology, Bird Diseases, microbiology, Body Weight, Campylobacter Infections, microbiology, Campylobacter jejuni, immunology, pathogenicity, Enzyme-Linked Immunosorbent Assay, Feces, microbiology, Humans, Passeriformes, classification, microbiology, Virulence, Zoonoses, microbiology, transmission
Ämneskategorier Mikrobiologi

Sammanfattning

Campylobacter jejuni is a common cause of bacterial gastroenteritis in most parts of the world. The bacterium has a broad host range and has been isolated from many animals and environments. To investigate shedding patterns and putative effects on an avian host, we developed a colonization model in which a wild bird species, the European Robin Erithacus rubecula, was inoculated orally with C. jejuni from either a human patient or from another wild bird species, the Song Thrush Turdus philomelos. These two isolates were genetically distinct from each other and provoked very different host responses. The Song Thrush isolate colonized all challenged birds and colonization lasted 6.8 days on average. Birds infected with this isolate also showed a transient but significant decrease in body mass. The human isolate did not colonize the birds and could be detected only in the feces of the birds shortly after inoculation. European Robins infected with the wild bird isolate generated a specific antibody response to C. jejuni membrane proteins from the avian isolate, which also was cross-reactive to membrane proteins of the human isolate. In contrast, European Robins infected with the human isolate did not mount a significant response to bacterial membrane proteins from either of the two isolates. The difference in colonization ability could indicate host adaptations.

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