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Genetic variability within the S100B gene influences the personality trait self-directedness.

Artikel i vetenskaplig tidskrift
Författare Petra Suchankova
Fariba Baghaei
Roland Rosmond
Göran Holm
Henrik Anckarsäter
Agneta Ekman
Publicerad i Psychoneuroendocrinology
Volym 36
Nummer/häfte 6
Sidor 919-23
ISSN 1873-3360
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 919-23
Språk en
Länkar dx.doi.org/10.1016/j.psyneuen.2010....
Ämneskategorier Fysiologi, Psykiatri

Sammanfattning

Elevated serum levels of S100B have proven useful as an indicator of brain-injury but have also been shown in patients diagnosed with psychiatric disorders. Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. The aim of the present study was to investigate whether some of these genetic variations influence general aspects of human behaviour as portrayed by normal dimensions of personality. Two single nucleotide polymorphisms within the S100B gene, 2757C>G and 5748C>T, were genotyped in two population based cohorts consisting of 42-year-old women (n=270) and 51-year-old men (n=247), respectively. The two polymorphisms were analysed with respect to personality traits assessed using the Temperament and Character Inventory (TCI). In men, the 2757C>G polymorphism was found to significantly influence the TCI dimension self-directedness with higher scores in 2757G homozygotes. A similar tendency towards association was seen in the female cohort; however, this correlation did not remain significant after correction for multiple comparisons. Furthermore, the 5748C>T polymorphism was highly associated with self-directedness in men. Self-directedness is an overall estimate of adaptive strategies to adjust behaviour to conceptual goals as well as coping strategies and is strongly correlated to general mental health and absence of personality disorder. These preliminary findings suggest that the S100B gene may be implicated not only in certain pathological brain conditions but also in processes involved in normal behaviour.

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