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Integrin and chemokine receptor gene expression in implant-adherent cells during early osseointegration.

Artikel i vetenskaplig tidskrift
Författare Omar Omar
Maria Lennerås
Sara Svensson
Felicia Suska
Lena Emanuelsson
Jan Hall
Ulf Nannmark
Peter Thomsen
Publicerad i Journal of materials science. Materials in medicine
Volym 21
Nummer/häfte 3
Sidor 969-80
ISSN 1573-4838
Publiceringsår 2010
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 969-80
Språk en
Länkar dx.doi.org/10.1007/s10856-009-3915-...
Ämnesord Animals, Cell Adhesion, Chemokines, chemistry, Female, Gene Expression Regulation, Integrins, chemistry, Microscopy, Electron, Scanning, methods, Osseointegration, Prostheses and Implants, Rats, Rats, Sprague-Dawley, Receptors, CXCR4, metabolism, Tibia, metabolism, Titanium, chemistry, Tumor Necrosis Factor-alpha, metabolism
Ämneskategorier Biomaterialvetenskap, Klinisk medicin

Sammanfattning

The mechanisms of early cellular recruitment and interaction to titanium implants are not well understood. The aim of this study was to investigate the expression of pro-inflammatory cytokines, chemokines and adhesion markers during the first 24 h of implantation. Anodically oxidized and machined titanium implants were inserted in rat tibia. After 3, 12, and 24 h the implants were unscrewed and analyzed with quantitative polymerase chain reaction. Immunohistochemistry and scanning electron microscopy revealed different cell types, morphology and adhesion at the two implant surfaces. A greater amount of cells, as indicated by higher expression of small subunit ribosomal RNA (18S), was detected on the oxidized surface. Higher expression of CXC chemokine receptor-4 (at 12 h) and integrins, alphav (at 12 h), beta1 (at 24 h) and beta2 (at 12 and 24 h) was detected at the oxidized surfaces. Significantly higher tumor necrosis factor-alpha (at 3 h) and interleukin-1beta (at 24 h) expression was demonstrated for the machined surface. It is concluded that material surface properties rapidly modulate the expression of receptors important for the recruitment and adhesion of cells which are crucial for the inflammatory and regenerative processes at implant surfaces in vivo.

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