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Levels of antibody against 11 Staphylococcus aureus antigens in a healthy population.

Artikel i vetenskaplig tidskrift
Författare Patricia Colque-Navarro
Gunnar Jacobsson
Rune Andersson
Jan-Ingmar Flock
Roland Möllby
Publicerad i Clinical and vaccine immunology : CVI
Volym 17
Nummer/häfte 7
Sidor 1117-23
ISSN 1556-679X
Publiceringsår 2010
Publicerad vid Institutionen för biomedicin
Sidor 1117-23
Språk en
Länkar dx.doi.org/10.1128/CVI.00506-09
Ämnesord Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Antibodies, Bacterial, analysis, Antigen-Antibody Reactions, Antigens, Bacterial, immunology, Antigens, Surface, immunology, Enzyme-Linked Immunosorbent Assay, Humans, Middle Aged, Staphylococcus aureus, immunology, Young Adult
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Serum samples from 151 healthy individuals aged from 15 to 89 years were investigated by enzyme-linked immunosorbent assay (ELISA) for IgG levels against 11 different purified antigens from Staphylococcus aureus. Surface antigens, such as teichoic acid, clumping factors A and B, and bone sialoprotein binding protein, and extracellular proteins, such as alpha-toxin, lipase, enterotoxin A, toxic shock syndrome toxin, scalded-skin syndrome toxin, fibrinogen binding protein, and extracellular adherence protein, were used. The IgG values were analyzed in relation to the state of nasal carriage at the time of sampling. There was great individual variation in antibody levels in both young and elderly healthy subjects. Occurrence of S. aureus in the nares at the time of sampling was correlated with higher antibody levels, while elderly individuals over 65 years of age showed slightly lower levels than younger adults. More individuals than was expected from random probability calculations showed high antibody levels against several antigens, and more individuals than would be expected showed low levels against several antigens. Certain extracellular proteins had more often induced IgG levels of the same magnitude in the same individuals, indicating that among these individuals, there was a tendency to respond to certain antigens in the same way. Most individuals had circulating IgG antibodies to the 11 tested antigens, and some individuals had the tendency to be "good responders" to several antigens, while others were "poor responders." These findings constitute basic knowledge for the development of improved serological diagnostics, immune prophylaxis, individual prognosis tools, and therapy against invasive Staphylococcus aureus infections.

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