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Antibody responses in patients with invasive Staphylococcus aureus infections.

Artikel i vetenskaplig tidskrift
Författare Gunnar Jacobsson
P Colque-Navarro
E Gustafsson
R Andersson
R Möllby
Publicerad i European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Volym 29
Nummer/häfte 6
Sidor 715-25
ISSN 1435-4373
Publiceringsår 2010
Publicerad vid Institutionen för biomedicin
Sidor 715-25
Språk en
Länkar dx.doi.org/10.1007/s10096-010-0919-...
Ämnesord Aged, Antibodies, Bacterial, blood, Antibody Formation, Antigens, Bacterial, diagnostic use, Bacterial Proteins, biosynthesis, immunology, Bacterial Toxins, biosynthesis, immunology, Bacterial Typing Techniques, DNA Fingerprinting, Electrophoresis, Gel, Pulsed-Field, Enzyme-Linked Immunosorbent Assay, methods, Hemolysin Proteins, biosynthesis, immunology, Humans, Middle Aged, Prospective Studies, Staphylococcal Infections, immunology, mortality, pathology, Staphylococcus aureus, classification, immunology, isolation & purification, pathogenicity, Trans-Activators, biosynthesis, immunology, Virulence Factors, biosynthesis, immunology
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Correlation between antibody response and clinical outcome in Staphylococcus aureus bacteremia has yielded conflicting results. Immunization schedules have failed in clinical trials. Is the humoral response toward S. aureus of protective nature? A prospective study was performed in patients with invasive S. aureus (ISA) infections during the period 2003-2005. The antibody levels were determined at the beginning and at the end of treatment and one month later (n = 96, n = 71, and n = 51, respectively). As controls, 115 healthy individuals were used. A quantitative enzyme-linked immunosorbent assay (ELISA) against eight purified antigens was performed. Bacterial isolates were grouped as to the production of alpha-toxin, agr type, and pulsed-field gel electrophoresis (PFGE) type. Large variations were seen in the antibody levels. The levels in the second sample were the highest. A correlation between agr group, PFGE group, alpha-toxin production, and initial antibody levels was observed. Patients with fatal outcome displayed lower initial antibody levels to all antigens and significantly so in regard to teichoic acid, lipase, enterotoxin A, and scalded skin syndrome toxin. In episodes with complicated bacteremia, initial significantly low levels to teichoic acid and lipase were registered. Low initial antibody levels against several antigens were associated with increased mortality and complicated bacteremia in invasive S. aureus infections. Bacterial properties, strain, and toxin production affected the antibody response.

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