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Bone formation following implantation of titanium sponge rods into humeral osteotomies in dogs: a histological and histometrical study.

Artikel i vetenskaplig tidskrift
Författare Paulo Esteves Pinto Faria
Alexandre Leite Carvalho
Daniela Nair Borges Felipucci
Cui'e Wen
Lars Sennerby
Luiz Antonio Salata
Publicerad i Clinical implant dentistry and related research
Volym 12
Nummer/häfte 1
Sidor 72-79
ISSN 1708-8208
Publiceringsår 2010
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 72-79
Språk en
Länkar dx.doi.org/10.1111/j.1708-8208.2008...
Ämnesord Animals, Biocompatible Materials, chemistry, Bone Diseases, pathology, surgery, Bone Marrow, pathology, Bone Substitutes, therapeutic use, Coloring Agents, diagnostic use, Disease Models, Animal, Dogs, Durapatite, therapeutic use, Humerus, pathology, surgery, Male, Osteogenesis, physiology, Osteotomy, methods, Pyronine, diagnostic use, Random Allocation, Time Factors, Tissue Scaffolds, Titanium, chemistry, Tolonium Chloride, diagnostic use
Ämneskategorier Patologi, Biomaterial


BACKGROUND: Titanium (Ti) is widely proven to enhance bone contact and growth on its surface. It is expected that bone defects could benefit from Ti to promote healing and to increase strength of the implanted area. PURPOSE: The present study aimed at comparing the potential of porous Ti sponge rods with synthetic hydroxyapatite (HA) for the healing of bone defects in a canine model. MATERIAL AND METHODS: Six mongrel dogs were submitted to three trephined osteotomies of 6.0 x 4.0 mm in one humerus and after 2 months another three osteotomies were performed in the contralateral humerus. A total of 36 defects were randomly filled either with Ti foam, particulate HA, or coagulum (control). The six animals were killed 4 months after the first surgery for histological and histometrical analysis. RESULTS: The Ti-foam surface was frequently found in intimate contact with new bone especially at the defect walls. Control sites showed higher amounts of newly formed bone at 2 months - Ti (p = 0.000) and HA (p = 0.009) - and 4 months when compared with Ti (p = 0.001). Differently from HA, the Ti foam was densely distributed across the defect area which rendered less space for bone growth in the latter's sites. The use of Ti foams or HA resulted in similar amounts of bone formation in both time intervals. Nevertheless, the presence of a Ti-foam rod preserved defect's marginal bone height as compared with control groups. Also, the Ti-foam group showed a more mature bone pattern at 4 months than HA sites. CONCLUSION: The Ti foam exhibited good biocompatibility, and its application resulted in improved maintenance of bone height compared with control sites. The Ti foam in a rod design exhibited bone ingrowth properties suitable for further exploration in other experimental situations.

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