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Preclinical in vivo models to study the inflammatory response to implants.

Paper i proceeding
Författare Peter Thomsen
Felicia Suska
Lena Emanuelsson
A Johansson
T. Jarmar
Håkan Engqvist
Publicerad i Abstract, Invited lecture, CIMTEC, Italy
Publiceringsår 2006
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Språk en
Ämneskategorier Klinisk medicin, Biomaterialvetenskap

Sammanfattning

The interactions between the material surface and cellular and molecular components in the interface tissue are key features in the selection of optimal materials for clinical use. A quantitative analysis of the inflammatory, reparative and regenerative processes which occur as a response to implant modifications is therefore required. A prerequisite for such analyses is the development of experimental models which allow an access to sampling and harvesting of interfacial molecules, cells and tissues for subsequent analyses. The lecture will provide an overview of the features of such models and examples from own studies where biochemical, immunological and morphological techniques may be combined. We have developed a simple, reproducible experimental model in vivo, allowing a detailed analysis of initial inflammatory events as well as later, reparative processes in association with implant surfaces. Studies on the role of material bulk and surface properties for inflammatory cell chemotaxis, viability and cytokine patterns around materials will be discussed using metals, polymers, bioceramics and surface functionalizations.

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