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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Artikel i vetenskaplig tidskrift
Författare Iris M Heid
Anne U Jackson
Joshua C Randall
Thomas W Winkler
Lu Qi
Valgerdur Steinthorsdottir
Gudmar Thorleifsson
M Carola Zillikens
Elizabeth K Speliotes
Reedik Mägi
Tsegaselassie Workalemahu
Charles C White
Nabila Bouatia-Naji
Tamara B Harris
Sonja I Berndt
Erik Ingelsson
Cristen J Willer
Michael N Weedon
Jian'an Luan
Sailaja Vedantam
Tõnu Esko
Tuomas O Kilpeläinen
Zoltán Kutalik
Shengxu Li
Keri L Monda
Anna L Dixon
Christopher C Holmes
Lee M Kaplan
Liming Liang
Josine L Min
Miriam F Moffatt
Cliona Molony
George Nicholson
Eric E Schadt
Krina T Zondervan
Mary F Feitosa
Teresa Ferreira
Hana Lango Allen
Robert J Weyant
Eleanor Wheeler
Andrew R Wood
Karol Estrada
Michael E Goddard
Guillaume Lettre
Massimo Mangino
Dale R Nyholt
Shaun Purcell
Albert Vernon Smith
Peter M Visscher
Jian Yang
Steven A McCarroll
James Nemesh
Benjamin F Voight
Devin Absher
Najaf Amin
Thor Aspelund
Lachlan Coin
Nicole L Glazer
Caroline Hayward
Nancy L Heard-Costa
Jouke-Jan Hottenga
Åsa Johansson
Toby Johnson
Marika Kaakinen
Karen Kapur
Shamika Ketkar
Joshua W Knowles
Peter Kraft
Aldi T Kraja
Claudia Lamina
Michael F Leitzmann
Barbara McKnight
Andrew P Morris
Ken K Ong
John R B Perry
Marjolein J Peters
Ozren Polasek
Inga Prokopenko
Nigel W Rayner
Samuli Ripatti
Fernando Rivadeneira
Neil R Robertson
Serena Sanna
Ulla Sovio
Ida Surakka
Alexander Teumer
Sophie van Wingerden
Veronique Vitart
Jing Hua Zhao
Christine Cavalcanti-Proença
Peter S Chines
Eva Fisher
Jennifer R Kulzer
Cecile Lecoeur
Narisu Narisu
Camilla Sandholt
Laura J Scott
Kaisa Silander
Klaus Stark
Mari-Liis Tammesoo
Tanya M Teslovich
Nicholas John Timpson
Richard M Watanabe
Ryan Welch
Daniel I Chasman
Matthew N Cooper
John-Olov Jansson
Johannes Kettunen
Robert W Lawrence
Niina Pellikka
Markus Perola
Liesbeth Vandenput
Helene Alavere
Peter Almgren
Larry D Atwood
Amanda J Bennett
Reiner Biffar
Lori L Bonnycastle
Stefan R Bornstein
Thomas A Buchanan
Harry Campbell
Ian N M Day
Mariano Dei
Marcus Dörr
Paul Elliott
Michael R Erdos
Johan G Eriksson
Nelson B Freimer
Mao Fu
Stefan Gaget
Eco J C Geus
Anette P Gjesing
Harald Grallert
Jürgen Gräßler
Christopher J Groves
Candace Guiducci
Anna-Liisa Hartikainen
Neelam Hassanali
Aki S Havulinna
Karl-Heinz Herzig
Andrew A Hicks
Jennie Hui
Wilmar Igl
Pekka Jousilahti
Antti Jula
Eero Kajantie
Leena Kinnunen
Ivana Kolcic
Seppo Koskinen
Peter Kovacs
Heyo K Kroemer
Vjekoslav Krzelj
Johanna Kuusisto
Kirsti Kvaloy
Jaana Laitinen
Olivier Lantieri
G Mark Lathrop
Marja-Liisa Lokki
Robert N Luben
Barbara Ludwig
Wendy L McArdle
Anne McCarthy
Mario A Morken
Mari Nelis
Matt J Neville
Guillaume Paré
Alex N Parker
John F Peden
Irene Pichler
Kirsi H Pietiläinen
Carl G P Platou
Anneli Pouta
Martin Ridderstråle
Nilesh J Samani
Jouko Saramies
Juha Sinisalo
Jan H Smit
Rona J Strawbridge
Heather M Stringham
Amy J Swift
Maris Teder-Laving
Brian Thomson
Gianluca Usala
Joyce B J van Meurs
Gert-Jan van Ommen
Vincent Vatin
Claudia B Volpato
Henri Wallaschofski
G Bragi Walters
Elisabeth Widen
Sarah H Wild
Gonneke Willemsen
Daniel R Witte
Lina Zgaga
Paavo Zitting
John P Beilby
Alan L James
Mika Kähönen
Terho Lehtimäki
Markku S Nieminen
Claes Ohlsson
Lyle J Palmer
Olli Raitakari
Paul M Ridker
Michael Stumvoll
Anke Tönjes
Jorma Viikari
Beverley Balkau
Yoav Ben-Shlomo
Richard N Bergman
Heiner Boeing
George Davey Smith
Shah Ebrahim
Philippe Froguel
Torben Hansen
Christian Hengstenberg
Kristian Hveem
Bo Isomaa
Torben Jørgensen
Fredrik Karpe
Kay-Tee Khaw
Markku Laakso
Debbie A Lawlor
Michel Marre
Thomas Meitinger
Andres Metspalu
Kristian Midthjell
Oluf Pedersen
Veikko Salomaa
Peter E H Schwarz
Tiinamaija Tuomi
Jaakko Tuomilehto
Timo T Valle
Nicholas J Wareham
Alice M Arnold
Jacques S Beckmann
Sven Bergmann
Eric Boerwinkle
Dorret I Boomsma
Mark J Caulfield
Francis S Collins
Gudny Eiriksdottir
Vilmundur Gudnason
Ulf Gyllensten
Anders Hamsten
Andrew T Hattersley
Albert Hofman
Frank B Hu
Thomas Illig
Carlos Iribarren
Marjo-Riitta Jarvelin
W H Linda Kao
Jaakko Kaprio
Lenore J Launer
Patricia B Munroe
Ben Oostra
Brenda W Penninx
Peter P Pramstaller
Bruce M Psaty
Thomas Quertermous
Aila Rissanen
Igor Rudan
Alan R Shuldiner
Nicole Soranzo
Timothy D Spector
Ann-Christine Syvanen
Manuela Uda
André Uitterlinden
Henry Völzke
Peter Vollenweider
James F Wilson
Jacqueline C Witteman
Alan F Wright
Gonçalo R Abecasis
Michael Boehnke
Ingrid B Borecki
Panos Deloukas
Timothy M Frayling
Leif C Groop
Talin Haritunians
David J Hunter
Robert C Kaplan
Kari E North
Jeffrey R O'Connell
Leena Peltonen
David Schlessinger
David P Strachan
Joel N Hirschhorn
Themistocles L Assimes
H-Erich Wichmann
Unnur Thorsteinsdottir
Cornelia M van Duijn
Kari Stefansson
L Adrienne Cupples
Ruth J F Loos
Inês Barroso
Mark I McCarthy
Caroline S Fox
Karen L Mohlke
Cecilia M Lindgren
Publicerad i Nature genetics
Volym 42
Nummer/häfte 11
Sidor 949-60
ISSN 1546-1718
Publiceringsår 2010
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin
Sidor 949-60
Språk en
Länkar dx.doi.org/10.1038/ng.685
Ämneskategorier Fysiologi

Sammanfattning

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10(-9) to P = 1.8 × 10(-40)) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10(-3) to P = 1.2 × 10(-13)). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

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