Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Association analyses of 2… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Artikel i vetenskaplig tidskrift
Författare Elizabeth K Speliotes
Cristen J Willer
Sonja I Berndt
Keri L Monda
Gudmar Thorleifsson
Anne U Jackson
Hana Lango Allen
Cecilia M Lindgren
Jian'an Luan
Reedik Mägi
Joshua C Randall
Sailaja Vedantam
Thomas W Winkler
Lu Qi
Tsegaselassie Workalemahu
Iris M Heid
Valgerdur Steinthorsdottir
Heather M Stringham
Michael N Weedon
Eleanor Wheeler
Andrew R Wood
Teresa Ferreira
Robert J Weyant
Ayellet V Segrè
Karol Estrada
Liming Liang
James Nemesh
Ju-Hyun Park
Stefan Gustafsson
Tuomas O Kilpeläinen
Jian Yang
Nabila Bouatia-Naji
Tõnu Esko
Mary F Feitosa
Zoltán Kutalik
Massimo Mangino
Soumya Raychaudhuri
Andre Scherag
Albert Vernon Smith
Ryan Welch
Jing Hua Zhao
Katja K Aben
Devin M Absher
Najaf Amin
Anna L Dixon
Eva Fisher
Nicole L Glazer
Michael E Goddard
Nancy L Heard-Costa
Volker Hoesel
Jouke-Jan Hottenga
Åsa Johansson
Toby Johnson
Shamika Ketkar
Claudia Lamina
Shengxu Li
Miriam F Moffatt
Richard H Myers
Narisu Narisu
John R B Perry
Marjolein J Peters
Michael Preuss
Samuli Ripatti
Fernando Rivadeneira
Camilla Sandholt
Laura J Scott
Nicholas J Timpson
Jonathan P Tyrer
Sophie van Wingerden
Richard M Watanabe
Charles C White
Fredrik Wiklund
Christina Barlassina
Daniel I Chasman
Matthew N Cooper
John-Olov Jansson
Robert W Lawrence
Niina Pellikka
Inga Prokopenko
Jianxin Shi
Elisabeth Thiering
Helene Alavere
Maria T S Alibrandi
Peter Almgren
Alice M Arnold
Thor Aspelund
Larry D Atwood
Beverley Balkau
Anthony J Balmforth
Amanda J Bennett
Yoav Ben-Shlomo
Richard N Bergman
Sven Bergmann
Heike Biebermann
Alexandra I F Blakemore
Tanja Boes
Lori L Bonnycastle
Stefan R Bornstein
Morris J Brown
Thomas A Buchanan
Fabio Busonero
Harry Campbell
Francesco P Cappuccio
Christine Cavalcanti-Proença
Yii-Der Ida Chen
Chih-Mei Chen
Peter S Chines
Robert Clarke
Lachlan Coin
John Connell
Ian N M Day
Martin den Heijer
Jubao Duan
Shah Ebrahim
Paul Elliott
Roberto Elosua
Gudny Eiriksdottir
Michael R Erdos
Johan G Eriksson
Maurizio F Facheris
Stephan B Felix
Pamela Fischer-Posovszky
Aaron R Folsom
Nele Friedrich
Nelson B Freimer
Mao Fu
Stefan Gaget
Pablo V Gejman
Eco J C Geus
Christian Gieger
Anette P Gjesing
Anuj Goel
Philippe Goyette
Harald Grallert
Jürgen Gräßler
Danielle M Greenawalt
Christopher J Groves
Vilmundur Gudnason
Candace Guiducci
Anna-Liisa Hartikainen
Neelam Hassanali
Alistair S Hall
Aki S Havulinna
Caroline Hayward
Andrew C Heath
Christian Hengstenberg
Andrew A Hicks
Anke Hinney
Albert Hofman
Georg Homuth
Jennie Hui
Wilmar Igl
Carlos Iribarren
Bo Isomaa
Kevin B Jacobs
Ivonne Jarick
Elizabeth Jewell
Ulrich John
Torben Jørgensen
Pekka Jousilahti
Antti Jula
Marika Kaakinen
Eero Kajantie
Lee M Kaplan
Sekar Kathiresan
Johannes Kettunen
Leena Kinnunen
Joshua W Knowles
Ivana Kolcic
Inke R König
Seppo Koskinen
Peter Kovacs
Johanna Kuusisto
Peter Kraft
Kirsti Kvaløy
Jaana Laitinen
Olivier Lantieri
Chiara Lanzani
Lenore J Launer
Cecile Lecoeur
Terho Lehtimäki
Guillaume Lettre
Jianjun Liu
Marja-Liisa Lokki
Mattias Lorentzon
Robert N Luben
Barbara Ludwig
Paolo Manunta
Diana Marek
Michel Marre
Nicholas G Martin
Wendy L McArdle
Anne McCarthy
Barbara McKnight
Thomas Meitinger
Olle Melander
David Meyre
Kristian Midthjell
Grant W Montgomery
Mario A Morken
Andrew P Morris
Rosanda Mulic
Julius S Ngwa
Mari Nelis
Matt J Neville
Dale R Nyholt
Christopher J O'Donnell
Stephen O'Rahilly
Ken K Ong
Ben Oostra
Guillaume Paré
Alex N Parker
Markus Perola
Irene Pichler
Kirsi H Pietiläinen
Carl G P Platou
Ozren Polasek
Anneli Pouta
Suzanne Rafelt
Olli Raitakari
Nigel W Rayner
Martin Ridderstråle
Winfried Rief
Aimo Ruokonen
Neil R Robertson
Peter Rzehak
Veikko Salomaa
Alan R Sanders
Manjinder S Sandhu
Serena Sanna
Jouko Saramies
Markku J Savolainen
Susann Scherag
Sabine Schipf
Stefan Schreiber
Heribert Schunkert
Kaisa Silander
Juha Sinisalo
David S Siscovick
Jan H Smit
Nicole Soranzo
Ulla Sovio
Jonathan Stephens
Ida Surakka
Amy J Swift
Mari-Liis Tammesoo
Jean-Claude Tardif
Maris Teder-Laving
Tanya M Teslovich
John R Thompson
Brian Thomson
Anke Tönjes
Tiinamaija Tuomi
Joyce B J van Meurs
Gert-Jan van Ommen
Vincent Vatin
Jorma Viikari
Sophie Visvikis-Siest
Veronique Vitart
Carla I G Vogel
Benjamin F Voight
Lindsay L Waite
Henri Wallaschofski
G Bragi Walters
Elisabeth Widen
Susanna Wiegand
Sarah H Wild
Gonneke Willemsen
Daniel R Witte
Jacqueline C Witteman
Jianfeng Xu
Qunyuan Zhang
Lina Zgaga
Andreas Ziegler
Paavo Zitting
John P Beilby
I Sadaf Farooqi
Johannes Hebebrand
Heikki V Huikuri
Alan L James
Mika Kähönen
Douglas F Levinson
Fabio Macciardi
Markku S Nieminen
Claes Ohlsson
Lyle J Palmer
Paul M Ridker
Michael Stumvoll
Jacques S Beckmann
Heiner Boeing
Eric Boerwinkle
Dorret I Boomsma
Mark J Caulfield
Stephen J Chanock
Francis S Collins
L Adrienne Cupples
George Davey Smith
Jeanette Erdmann
Philippe Froguel
Henrik Grönberg
Ulf Gyllensten
Per Hall
Torben Hansen
Tamara B Harris
Andrew T Hattersley
Richard B Hayes
Joachim Heinrich
Frank B Hu
Kristian Hveem
Thomas Illig
Marjo-Riitta Jarvelin
Jaakko Kaprio
Fredrik Karpe
Kay-Tee Khaw
Lambertus A Kiemeney
Heiko Krude
Markku Laakso
Debbie A Lawlor
Andres Metspalu
Patricia B Munroe
Willem H Ouwehand
Oluf Pedersen
Brenda W Penninx
Annette Peters
Peter P Pramstaller
Thomas Quertermous
Thomas Reinehr
Aila Rissanen
Igor Rudan
Nilesh J Samani
Peter E H Schwarz
Alan R Shuldiner
Timothy D Spector
Jaakko Tuomilehto
Manuela Uda
André Uitterlinden
Timo T Valle
Martin Wabitsch
Gérard Waeber
Nicholas J Wareham
Hugh Watkins
James F Wilson
Alan F Wright
M Carola Zillikens
Nilanjan Chatterjee
Steven A McCarroll
Shaun Purcell
Eric E Schadt
Peter M Visscher
Themistocles L Assimes
Ingrid B Borecki
Panos Deloukas
Caroline S Fox
Leif C Groop
Talin Haritunians
David J Hunter
Robert C Kaplan
Karen L Mohlke
Jeffrey R O'Connell
Leena Peltonen
David Schlessinger
David P Strachan
Cornelia M van Duijn
H-Erich Wichmann
Timothy M Frayling
Unnur Thorsteinsdottir
Gonçalo R Abecasis
Inês Barroso
Michael Boehnke
Kari Stefansson
Kari E North
Mark I McCarthy
Joel N Hirschhorn
Erik Ingelsson
Ruth J F Loos
Publicerad i Nature genetics
Volym 42
Nummer/häfte 11
Sidor 937-48
ISSN 1546-1718
Publiceringsår 2010
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin
Centre for Bone and Arthritis Research
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Sidor 937-48
Språk en
Länkar dx.doi.org/10.1038/ng.686
Ämneskategorier Fysiologi

Sammanfattning

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?