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Influence of chronic hormone replacement therapy on left ventricular mass and serum-ACE activity.

Artikel i vetenskaplig tidskrift
Författare Karin Manhem
Bachar Ghanoum
Magnus C Johansson
Ian Milsom
Helena Gustafsson
Publicerad i Blood pressure
Volym 19
Nummer/häfte 5
Sidor 295-300
ISSN 1651-1999
Publiceringsår 2010
Publicerad vid Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin
Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
Sidor 295-300
Språk en
Länkar dx.doi.org/10.3109/08037051.2010.48...
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

AIMS: The aim of this investigation was to study the effects of hormone replacement therapy (HRT) on left ventricular mass (LVM) and serum-angiotensin-converting enzyme (ACE) activity (S-ACE) in well controlled hypertensive postmenopausal women. METHODS: In this prospective, randomized, crossover, double-blind trial we studied 20 well controlled hypertensive postmenopausal women who received 6 months of HRT and 6 months of placebo on top of antihypertensive treatment. Two-dimensional M-mode, office blood pressure, 24-h ambulatory blood pressure (ABPM), S-estradiol and S-ACE activity were investigated at baseline, after 6 and 12 months. RESULTS: LVM was significantly influenced by HRT (analysis of variance, ANOVA, p<0.01). However, the order in randomization of HRT and placebo had an impact on the analysis of LVM reduction (baseline - HRT - placebo: ns; baseline - placebo - HRT: p<0.01 ANOVA). Only the women lacking blockade of the renin-angiotensin-aldosterone system (RAAS) as antihypertensive treatment (n=10) experienced a reduction in LVM and a tendency of decreased S-ACE activity in response to HRT compared with baseline (p< 0.05 and p= 0.06 respectively). CONCLUSIONS: Six months of HRT resulted in significant reduction of LVM without any change in ABPM. HRT may reduce LVM through interaction with the RAAS, since hypertensive women without RAAS blockade exhibited an effect of HRT on LVM and S-ACE activity, which was not seen in women on RAAS blockade.

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