Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Pittsburgh compound-B and… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study.

Artikel i vetenskaplig tidskrift
Författare M Degerman Gunnarsson
M Lindau
A Wall
Kaj Blennow
T Darreh-Shori
S Basu
A Nordberg
A Larsson
L Lannfelt
H Basun
L Kilander
Publicerad i Dementia and geriatric cognitive disorders
Volym 29
Nummer/häfte 3
Sidor 204-12
ISSN 1421-9824
Publiceringsår 2010
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 204-12
Språk en
Länkar dx.doi.org/10.1159/000281832
Ämnesord Aged, Alzheimer Disease, metabolism, radionuclide imaging, Amyloid beta-Protein, blood, cerebrospinal fluid, urine, Aniline Compounds, analysis, metabolism, Apolipoproteins E, genetics, Biological Markers, blood, cerebrospinal fluid, urine, Brain, radionuclide imaging, Cognition, physiology, Data Interpretation, Statistical, Education, Enzyme-Linked Immunosorbent Assay, Female, Glucose, metabolism, Humans, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Psychiatric Status Rating Scales, Psychometrics, Radiopharmaceuticals, diagnostic use, Risk Factors, Thiazoles, analysis, metabolism
Ämneskategorier Psykiatri

Sammanfattning

BACKGROUND: The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PIB) is an in vivo ligand for measuring beta-amyloid (Abeta) load. Associations between PET PIB and cerebrospinal fluid (CSF) Abeta1-42 and apolipoprotein E epsilon4 (APOE epsilon4) have been observed in several studies, but the relations between PIB uptake and other biomarkers of Alzheimer's disease (AD) are less investigated. METHOD: PET PIB, PET 18Fluoro-2-deoxy-D-glucose and different AD biomarkers were measured twice in CSF, plasma and urine 12 months apart in 10 patients with a clinical diagnosis of mild to moderate AD. RESULTS: PIB retention was constant over 1 year, inversely related to low CSF Abeta1-42 (p = 0.01) and correlated positively to the numbers of the APOE epsilon4 allele (0, 1 or 2) (p = 0.02). There was a relation between mean PIB retention and CSF ApoE protein (r = -0.59, p = 0.07), and plasma cystatin C (r = -0.56, p = 0.09). CONCLUSION: PIB retention is strongly related to CSF Abeta1-42, and to the numbers of the APOE epsilon4 allele.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?