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Bone ingrowth in zirconia and hydroxyapatite scaffolds with identical macroporosity.

Artikel i vetenskaplig tidskrift
Författare Johan Malmström
Erik Adolfsson
Lena Emanuelsson
Peter Thomsen
Publicerad i Journal of materials science. Materials in medicine
Volym 19
Nummer/häfte 9
Sidor 2983-92
ISSN 0957-4530
Publiceringsår 2008
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 2983-92
Språk en
Länkar dx.doi.org/10.1007/s10856-007-3045-...
Ämnesord Animals, Bone and Bones, drug effects, metabolism, Computer-Aided Design, Durapatite, chemistry, Female, Femur, drug effects, Materials Testing, Osseointegration, Osteogenesis, Porosity, Rabbits, Software, Surface Properties, Tibia, drug effects, Zirconium, chemistry
Ämneskategorier Biomaterialvetenskap, Klinisk medicin

Sammanfattning

The role of the material composition, porosity and surface topography of scaffolds for promotion of osteogenesis and osseointegration is not fully understood. The aim of the present study was to evaluate the effects of material composition and surface topography on bone ingrowth and bone contact. Designed macroporous ceramic scaffolds of zirconia and hydroxyapatite were used. Using free form fabrication (FFF) techniques an identical macroporosity in both materials was achieved. The scaffolds were implanted in rabbit tibia (cortical bone) and femur (trabecular bone). After 6 weeks of implantation the tissue response was assessed with histology and histomorphometry. The results showed significantly more bone ingrowth and bone contact in the hydroxyapatite scaffolds compared to the zirconia scaffold. Surface topography had no significant effect on bone contact inside the macropores regardless of material. This was observed in both cortical and trabecular bone sites. The study suggests that the difference between hydroxyapatite and zirconia was due to a difference in material chemistry.

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